Benefactor The - Harvard Medical School - Harvard University

Benefactor The - Harvard Medical School - Harvard University

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The

Benefactor partners in discovery partnership in discovery

A quest for healthy, productive aging motivates giving

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n 1965, Paul Glenn launched the Glenn Foundation for Medical Research in his quest to extend the healthy productive years of life through research on the mechanisms of biological aging. In 2005, his mission led him to Harvard Medical School, where the first of two generous gifts of $5 million established the Paul Glenn Laboratories for the Biological Mechanisms of Aging. Glenn made his second gift in 2009.

“We’re not aiming to fill nursing homes,” says Glenn, whose foundation also funds aging research labs at MIT and the Salk Institute for Biological Studies. The average American today lives 79 years, says Bruce Yanker, MD, HMS professor of pathology and co-director with David Sinclair, MD, of the Paul Glenn Laboratories for Biological Mechanisms of Aging. Yanker is leading research

focused on the downside of this longevity: an increase in neurodegenerative diseases, including Alzheimer’s. The Glenn Laboratories at HMS are dedicated to understanding the mechanisms of normal aging and the development of interventions to delay its onset and progression, thereby extending the healthy years of human life. Since 2006, an annual symposium, sponsored by the Glenn Labs, brings together some of the country’s most preeminent researchers in aging to exchange ideas. Many leaders in the aging field predict that significant strides will be made in understanding how human health and lifespan are regulated and how healthy lifespan is extended. The goal is to translate these discoveries into therapies that could postpone and treat diseases of aging.

Paul Glenn (left), founder of the Glenn Foundation for Medical Research, hosts an annual symposium at HMS that draws researchers on aging from around the country.” Dean Jeffrey Flier, MD, welcomed the attendees.

“We’re not aiming to fill nursing homes.” —Paul Glenn

Training the first generation of autism specialists

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lthough autism affects 1 out of 150 children in some form, according to the U.S. Centers for Disease Control and Prevention, little is known about the neurological disorder, which affects a person’s ability to communicate, engage in social interactions, and respond appropriately to his or her environment. The cause is not clear, there is no cure—and no test can detect it.

The first Nancy Lurie Marks Clinical and Research Fellows are (left to right) Michael Coulter, MD ’12, Katharine Clapham, MD ’12, and David Lin MD ’12.

Much of the reason little is known about the disorder is that there are so few physicians who understand autism and the needs of patients affected by it.

“I’ve spent a lifetime looking for answers and searching the best treatments for people with autism. Now that Harvard has joined in this quest, it is my hope that this new partnership will result in new treatments for people with autism, and hope for their families.” —Nancy Lurie Marks

To help address the demand for more physicians who work with both pediatric and adult autism patients, the Nancy Lurie Marks Family Foundation has provided $5 million to the Harvard Medical School to establish the Nancy Lurie Marks Clinical and Research Fellowship Program in Autism. The multifaceted program furnishes funding for HMS students and junior faculty members interested in pursuing a deeper understanding of autism and neurological disorders, and supports the Medical School’s focus on neuroscience. Half of the faculty members’ time will be spent seeing patients in the clinic. Lurie Marks, who has as an adult family member with autism, says the new program is a leap forward in autism research. “I’ve spent a lifetime looking for answers and searching the best treatments for people with autism,” she says. “Now that Harvard has joined in this quest, it is my hope that this new partnership will result in new treatments for people with autism, and hope for their families.”

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Deans at Harvard Medical School

Dear Friends, It is my great pleasure to welcome you to the inaugural issue of The Benefactor: Partners in Discovery, our bi-annual publication to honor and acknowledge our most generous friends and supporters. You make possible so much of the success that defines Harvard Medical School. Home to the largest community of biomedical researchers in the world, the breakthroughs that happen here transform our understanding of human disease. Harvard medical faculty are leaders in all areas of medicine and healthcare policy. Our innovative medical school curriculum is a model for schools nationwide. This level of excellence and international leadership is thanks in large part to all of you, Harvard Medical School’s partners in discovery. Your ongoing generous support ensures that we continue to be the best medical school and research center in the country, if not the world. Among our many partners featured in this issue is Paul Glenn, whose $5 million gift from the Glenn Foundation for Medical Research is advancing research into the mechanisms of biological aging in order to increase our understanding of how to extend our productive years. Nancy Lurie Marks has made a generous $5 million gift from the Nancy Lurie Marks Family Foundation to study autism and specifically, to create the next generation of physicians and researchers focused on autism. The first Marks Fellows—see their picture in this issue—represent the initial step of what we believe will be a future in better care for people with autism and support for their families. We also bring you the story of a very special alum, the late James “Bud” Stillman, MD ’32. Descended from a long line of philanthropic Harvard men, Stillman left a legacy in an $8 million trust that will provide scholarship support to HMS students for years to come. This issue also features stories about two longtime HMS partners: the National Multiple Sclerosis Society and the Foundation Fighting Blindness. These incredible organizations are helping to advance our research to unveil the genetics of multiple sclerosis and hereditary blindness respectively. Thank you for your continued commitment to Harvard Medical School and for all you do to support the great work that happens here.

Regards,

Susan Rapple Dean for Resource Development

Jeffrey Flier, MD Dean of the Harvard University Faculty of Medicine Gretchen Brodnicki, JD Dean for Faculty and Research Integrity Maureen Connelly, MD, MPH Acting Dean for Faculty Affairs Jules Dienstag, MD Dean for Medical Education Daniel Ennis, MBA, MPA Executive Dean for Administration David Golan, MD, PhD Dean for Graduate Education Richard Mills, JD Dean for Operations and Business Affairs Lee Nadler, MD ’73 Dean for Clinical and Translational Research Nancy Oriol, MD ’79 Dean for Students Susan Rapple Dean for Resource Development Joan Reede, MD, MBA Dean for Diversity and Community Partnership Nancy Tarbell, MD Dean for Academic and Clinical Affairs

The Benefactor: Partners in Discovery is produced by the Harvard Medical School Office of Resource Development, 401 Park Drive, Suite 22 West, Boston, MA 02215. ©2010 President and Fellows of Harvard University Dean for Resource Development Susan Rapple Editor Terri Rutter Design Sametz Blackstone Associates Photography Steve Gilbert Liza Greene Stuart Darsch Leonard Rubenstein Writer Elizabeth Franks

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A legacy creates a long future of scholarship support

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he late James “Bud” Stillman, MD ’32, made sparks fly. During his lifetime, he—a third generation Harvard man—was a pyrotechnic expert who in 1992, put on a fireworks display at the Statue of Liberty in New York Harbor. Beyond his hobby, however, he also created a fire for numerous medical students who would benefit from the Stillman Scholarship Fund he established. An obstetrician and gynecologist for three decades, Stillman passed away in 1998, bequeathing $8 million charitable remainder trust to Harvard Medical School to forward this mission. The trust was realized in 2009.

Stillman believed that all the medical advancements in the world were only useful if the best and brightest medical students were available to make the most of them. To make that possible, he wanted to give smart young people the opportunity to come to Harvard Medical School, regardless of their financial circumstances. His generous bequest will ensure this possibility for many students for years to come.

Bud Stillman wanted the best and brightest medical students to be able to come to Harvard Medical School, regardless of their financial situations.

Read about our partners in discovery, find updates and news about breakthroughs at HMS, and learn about all the ways you can support this vital work.

visit give.hms.harvard.edu

The Stillman Scholarship Fund is the last in a long line of gifts from the Stillman family to benefit medicine in Boston; the first was in 1901, when the senior Stillman made possible the opening of the Stillman Infirmary on Harvard’s main campus. The Fund is also a fitting legacy for Bud Stillman, of whom a favorite family story about his diagnosing his son’s Addison disease long-distance while the latter was in Switzerland and Bud was home in Texas underscored his own pride in his Harvard Medical School training.

Long-time benefactors to HMS continue to support student scholarships

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arold Spear, MD ’47, and his wife, Suzanne, believe in the value of education. Grateful to have both had wonderful educations themselves, they have focused their generous philanthropic giving on their favorite educational institutions. For several years, Harvard Medical School has been a fortunate beneficiary, including a $1 million charitable remainder trust in 2000, with another $25,000 added in 2008. The Spears also established a $50,000 charitable gift annuity in 2009 for Suzanne as well as naming HMS as the beneficiary of $250,000 in a trust managed outside of Harvard.

“We think education is the key to the strength of families, communities, our country, and the world,” says Suzanne. “It’s like a small ripple in the pond.” All of the Spears’ gifts are directed to the Suzanne and Harold Spear, MD ’47 Endowed Scholarship Fund. Suzanne recalls her late stepfather, who paid his way through medical school by shoveling coal. “Young people who can’t afford their own financial situation at HMS should still be able to come to school here,” she says.

Volume One; Issue One covers gifts and new pledges of $100,000 and above for individuals and $250,000 and above for organizations between July 1 and December 31, 2009. For information, please contact Terri Rutter, Senior Director of Development Communications, Harvard Medical School, (617) 384-8529 or [email protected]

The late James “Bud” Stillman, MD ’32 created a legacy that will support Harvard Medical students for generations to come.

Harold Spear, MD ’47, and his wife, Suzanne, are long time benefactors of Harvard Medical School.

“We think education is key.” —Suzanne Spears

corporate and foundation gifts $250,0000 – $999,999

The Simons Foundation gave $992,789 to support the research of Bernardo Sabatini, MD, PhD, Assistant Professor of Neurobiology. With genetic evidence linking autism with defects in signaling between neurons, this gift will allow Sabatini’s lab to study how neuron activity affects synapse formation, focusing on the role of three autism-associated proteins in this pathway. The Simons Foundation advances research in basic science and mathematics, and they hope to “stimulate collaborations and facilitate the exchange of new ideas that will further advance research in the life sciences.”

The G. Harold & Leila Y. Mathers Foundation made a gift of $992,789 to further the work of research of Bernardo Sabatini, MD, PhD, Assistant Professor of Neurobiology. This gift will further studies uncovering the mechanisms of synapse regulation in the brain and how changes in that system likely contribute to development of Tuberous Sclerosis Complex, an Autism Spectrum Disorder and Alzheimer’s Disease. The Mathers Foundation supports basic research in the life sciences.

The Brain Science Foundation gave $987,426 to support the Steven and Kathleen Haley Professorship in Neurosurgery. In keeping with the foundation’s mission to strengthen and expedite research for primary brain tumors, the Brain Science Foundation founders, Steven and Kathleen Haley, created this professorship at Harvard and Brigham and Women’s Hospital to enhance the excellence of investigation into brain tumors and related topics. The Professorship was created in honor of Peter Black, MD, PhD, Franc Ingraham Professor of Neurosurgery.

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Trip to Africa brings home impact of giving

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Friend’s gift is put immediately to good use

A longstanding relationship of firsts

William Helman’s children, Bea and Wilson, and his wife, Daisy, met with Paul Farmer, MD ’90 during a trip to Rwanda to see Farmer’s work first hand.

With its interdisciplinary faculty of social scientists and physicians, the Department of Global Health and Social Medicine applies social science and humanities research to constantly improve the practice of medicine, the delivery of treatment, and the development of health care policies locally and worldwide. Its members are concerned with the historical, cultural, and ethnic aspects of health care, poverty, and other social problems intimately interconnected with disease, and with the moral issues that arise in the practice of medicine today. “We need more programs that train physicians in delivery science,” says Farmer. “We’re building a trajectory for Global Health.”

“There is only one Paul Farmer.” —Chris Flowers

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any families embark on intercontinental vacations, but very few from the United States head to Rwanda. William Helman IV took his wife and their two children, ages 15 and 17, to the African country so they could see first-hand the work of Paul Farmer, MD ’90, chair of the Department of Global Health and Social Sciences. Farmer with his colleagues at Partners in Health manage an extensive network of hospitals, clinics and community health workers with the support of the Rwandan government.

hand the tremendous impact Paul has had on a substantial part of the Rwandan population and we all returned totally blown away and motivated to help.” The Helman family was inspired by the Harvard Medical School’s global health initiative, set up to address the medical needs of the world’s poorest people in Haiti, Peru, Rwanda, and even here in Boston. “With the incredible effort led by Paul and Howard Hiatt and others, it is awfully hard to stand around and not help,” Helman says of his

“It’s the least you can do.” —William Helman IV Inspired and wanting to do more, the Helmans made a generous gift to support Farmer’s efforts. “Seeing Paul and his team in the field is quite an experience,” says Helman. “there is no substitute for witnessing first

gift to support Farmer. “they have the right approach to this global issue and they are making a gigantic difference in our world.”

A desire to make a difference for others with MS inspires giving the world to advance research and treatment for neurodegenerative diseases.

William Edgerly and his wife, Lois, know first-hand the trials of multiple sclerosis (MS), a slow and oftentimes painful neurodegenerative disease. Lois was diagnosed with MS 50 years ago. Motivated to find better therapies, the Edgerlys have been generous supporters of the Harvard NeuroDiscovery Center, which develops collaborations around Harvard and throughout

In 2003, the couple made a $1 million gift to support the International Multiple Sclerosis Consortium, an initiative to identify all genetic risk factors for MS. In 2009, they followed with a pledge of $500,000 to support the Pathway to MS Drug Discovery Program. Already, their generosity has made an impact: in 2007, the Consortium announced it had identified several genetic markers for the disease. “Our hope is for MS cures,” say the Edgerlys. “We are fortunate to be able to help that effort.”

“Our hope is for MS cures.” —William and Lois Edgerly

Back in 1974, the young foundation was looking to award its first research grant addressing blindness caused by hereditary retinal degenerative diseases. They found Berson, one of the few doing research of that kind at the time. That initial grant established the HMS Berman-Gund Laboratory for the Study of Retinal Degenerations in partnership with the Massachusetts Eye and Ear Infirmary, with Berson as the lab’s director. The lab is named after foundation co-founders Bernard Berman and Gordon Gund, AB ’61, who went blind due to retinal degeneration as a young adult.

Rose praised Berson’s leadership in the field, and says his research has led to numerous firsts, including the development of a diagnostic tool that measures electrical signals in the retina that can tell physicians how fast retinal degeneration is progressing in the patient. Berman also discovered that injecting Vitamin A into the retina can help stem blindness in some individuals.

he relationship between Eliot Berson, MD ’62, Harvard Medical School, and the Foundation Fighting Blindness is built on firsts.

When Chris Flowers received an appeal from Paul Farmer, MD ’90, chair of the HMS Department of Global Health and Social Medicine, he didn’t think twice before making a gift of $100,000 to support the Department’s Program in Disease and Social Change. “Paul Farmer is an extraordinary and unique individual,” says Flowers. “There is only one Paul Farmer.”

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The lab is especially significant because it is the first cohesive center that takes a multi-pronged approach to understanding retinal diseases, according to Steve Rose, PhD, the foundation’s chief research officer.

Gordon Gund co-founded the Foundation Fighting Blindness in the early 1970s to support research to end hereditary blindness.

“Eliot and his group are responsible for major advances in understanding retinal degenerative diseases that lead to significantly impaired vision and total blindness.” —Steve Rose, PhD

The Owings Mills, Maryland-based foundation has supported the laboratory every year since then, with grants totaling $10.5 million to date, including $1.7 million in 2009.

A charitable trust is a good choice for all concerned Douglas Payne and his wife, Geraldine, who don’t have children, made the choice years ago that the majority of their assets would go to charity. Among Douglas’s first choice was Harvard—Douglas holds an undergraduate degree from Harvard, Class of 1962 and he graduated from Harvard Medical School, Class of 1966. His best option was a charitable remainder trust—a smart choice, as it supports both alma maters while also giving him a reliable return for the rest of his life. He recently made a $750,000 contribution to his trust to be divided evenly between the two schools upon his passing. “Harvard has a good record of managing the endowment,” says Payne. “I know the funds will be managed better than if I were managing them.” A charitable remainder trust is one of many vehicles that enable those over 55 to make smart money management strategies to support HMS and themselves at the same time.

“I know the funds will be managed better than if I were managing them.” —Douglas Payne

corporate and and foundation foundation gifts gifts $250,0000 $250,0000 –– $999,999 $999,999 corporate

The Commonwealth Fund gave $900,000 to support the Commonwealth Fund/Harvard University Fellowship Program in Minority Health Policy; a one-year, full-time program designed to create physician-leaders who will pursue careers in minority health and health policy. Under the direction of Joan Reede, MD, MPH, MBA, HMS Dean for Diversity and Community Partnership, the fellowship combines an intensive year of training in health policy, public health, and management with special program activities on minority health issues.

The ALS Therapy Alliance (ATA) gave $700,000 to support the work of Adrian Ivinson, PhD, founding Director of the Harvard NeuroDiscovery Center. This gift will support the NeuroDiscovery Center’s work focused on ending the suffering and improving the lives of the millions of people who face the physical, emotional, and economic burden of amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease. Ivinson and colleagues have developed a unique approach to understanding and treating neurodegenerative diseases like ALS. The ATA supports the advancement of studies into ALS.

The Burroughs Wellcome Fund (BWF) made a gift of $605,000 to support the work of Sandeep Robert Datta, MD, PhD, Assistant Professor of Neurobiology. BWF is funding Datta’s project, “characterization of neural circuits that drive innate behaviors.” The goal of his research is to determine how the brain is wired to extract information from the environment and convert that information into action. BWF’s “overall grant making strategy is to support biomedical scientists at the beginning of their careers and to make grants in areas of science that are poised for significant advancement, but are currently undervalued and underfunded.”

Takeda Pharmaceuticals gave $600,000 to support the Sleep and Health Education Program—a world-class, web-based education program on sleep science, sleep health and sleep disorders—under the direction of Charles Czeisler, MD, PhD, FRCP, the Baldino Professor of Sleep Medicine and Director, Division of Sleep Medicine. With Takeda’s gift, this program will help people recognize sleep problems, provide clinicians with the information they need to recognize and respond to patients’ sleep-related problems, and help educate medical students about healthy sleep.

The Rita Allen Foundation designated Samara Reck-Peterson, PhD, Assistant Professor of Cell Biology, the 2009 Milton Cassel Scholar and gave $550,000 to support her project “The Molecular Mechanism of Cytoplasmic Dynein.” Reck-Peterson is interested in understanding the mechanisms underlying intracellular transport and cell division, in particular the roles played by microtubules and microtubule-based molecular motors like dynein. The Rita Allen Foundation’s mission is to promote the Common Good by supporting medical research and treatment. The Foundation “intends to be flexible enough to respond to unique challenges, ideas and projects that lie beyond our identified program areas.”

“Eliot and his group are responsible for major advances in understanding retinal degenerative diseases that lead to significantly impaired vision and total blindness,” Rose says.

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Collaboration proves successful in identifying genetic risk factors for MS

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ince its founding in 1946, the National Multiple Sclerosis Society has been at the core of every major breakthrough in treating and understanding this debilitating disease. For more than 40 years, the Society has partnered with HMS to support groundbreaking MS research, contributing more than $42 million to HMS researchers in the last decade.

Joyce Nelson, President and CEO of the National Multiple Sclerosis Society, is partnering with HMS to end this disease.

“We’re committed to stopping this disease in its tracks.” —Joyce Nelson

“It’s a long journey and there are multiple pieces of the puzzle,” says Joyce Nelson, National MS Society President and CEO. “We’re committed to stopping this disease in its tracks.” In 2009, the Society committed another $2 million to support the International MS Genetics Consortium, a transformative initiative based within the Harvard NeuroDiscovery Center founded to identify genetic risk factors for multiple sclerosis. Before the launch of this project, and despite the efforts of many research teams working independently, only one risk factor had been discovered.

The solution, determined David Hafler, MD, HMS professor of neurology and consortium leader, was to work together. In 2007, Hafler and his colleagues published in the New England Journal of Medicine the identification of several new genetic factors in MS. “What makes this valuable went beyond the science,” says Nelson, who notes the project now includes 22 institutions. “These collaborators were formerly competitors who are now working together to achieve a shared goal.” When the study ends in 2010, most of the common genetic variants that predispose to MS will be known—information that will ultimately help identify people at risk, help predict how severely a person might be affected, and advance therapies.

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CGA offers a great way to accomplish two goals at once “It’s always been a goal of mine to give to the schools where I’ve gone,” says John Snyder, MD ’63. His 2009 charitable gift annuity, CGA, for $130,000 is a good way to give to HMS while also creating a fixed annual income for him for the rest of his life. The CGA, he says, had been on his mind for several years when friends of his opened one. He says he had always intended to do something at some point, and then with the crash of the stock market and all his other investments went down, everything came together at the right time. “This is a really good idea,” says Snyder, who appreciates that in addition to benefiting himself, he is supporting ground-breaking research and providing student scholarship support at HMS. “I would definitely recommend it.”

“This is a really good idea. I would definitely recommend it.” —John Snyder, MD ’63

Unlocking the mysteries of aging

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ging – we’ll do just about anything to slow it down or at least make it look like we have. But while many of us accept that it’s a fact of life, a new grant by the Ellison Medical Foundation seeks to unlock some of the secrets behind the aging process itself. The roughly $1 million gift funds Harvard Medical School research that looks at various reasons why genetically similar organisms have significantly different life spans. The researchers will seek to answer this question by comparing the genetic makeup of mice, which live up to four years, with naked mole rats, which are capable of living more than 28 years. The long-term goal is to identify and characterize naked mole-rat genes that contribute to the animal’s longevity, as well as its resistance to certain age-related diseases. Part of the project also involves developing revolutionary technology

The Ellison Medical Foundation, based in Bethesda, MD, supports biomedical research on aging, including that related to lifespan development processes and various age-related diseases and disabilities.

Herbert Morgan, MD ’42 met with HMS Dean Jeffrey S. Flier, MD, on a recent visit to the School.

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f it weren’t for a chance encounter with Hans Zinsser, MD, halfway through medical school, Herbert Morgan, MD ’42, might never have become a physician, nor would he have become the generous HMS benefactor he is now.

Morgan was working in a lab one day when Zinsser, one of his professors at Harvard Medical School, passed by and asked how things were going.

that will also allow researchers to automate parts of the process. Researchers in turn hope to use the same overall procedure to learn about how humans age. “The project is extremely worthwhile on two fronts—both in terms of the technology we’re helping develop, and the progress we can make in comparative genomics involving species with interesting aging properties,” says HMS genetics professor George Church, PhD, the lead investigator on the project.

Paying it forward by supporting junior faculty

George Church, PhD, is focused on research to understand why seemingly similar species have very different life spans.

Morgan, who was self-financing his education but was close to running out of money, told Zinsser he didn’t know if he could return to school the following year. Days later, Zinsser handed Morgan a letter from HMS Dean Sidney Burwell, MD, stating Morgan’s tuition would be covered until graduation.

“The project is extremely worthwhile on two fronts.” —George Church, PhD

In 1996, Morgan began returning the generosity shown to him by Zinsser and Burwell by establishing the Herbert Morgan, MD-Hans

The American Cancer Society (ACS) made a gift of $471,000 to support the work of Nancy Keating, MD, MPH, Associate Professor of Medicine and Health Care Policy. The ACS funding is allowing Keating to examine the influence of Massachusetts health insurance reform on breast cancer screening and diagnosis. Keating’s research focuses on the quality of care delivered to patients with cancer. Much of her current research examines the influence of physicians, hospitals, and health care systems on care delivery for patients with cancer. “As the nation’s largest private, not-for-profit source of funds for scientists studying cancer, ACS focuses its funding on investigator-initiated, peer-reviewed proposals.”

The fellowships support junior faculty who have shown excellence in medical education and teaching through a yearlong fellowship that includes lectures, interactive workshops, readings, essays, and a final project addressing teaching techniques.

“It’s a joy to know that my support has helped make contributions in teaching and research possible.” —Herbert Morgan, MD ’42

corporate and and foundation foundation gifts gifts $250,0000 $250,0000 –– $999,999 $999,999 corporate

The Breast Cancer Research Foundation (BCRF) made a gift of $500,000 to support cutting-edge breast cancer research in the Department of Cell Biology, led by Chair Joan Brugge, PhD. The Brugge laboratory is investigating the cellular processes and pathways involved in normal morphogenesis of epithelial tissues, and the initiation and progression of epithelial tumors related to breast cancer. BCRF’s mission is “to achieve prevention and a cure for breast cancer in our lifetime by providing critical funding for innovative clinical and translational research at leading medical centers worldwide, and increasing public awareness about good breast health.”

Zinsser, MD Teaching Fellowships in Medical Education at HMS with $3.8 million in support to date, including $1.4 million in 2009.

The James S. McDonnell Foundation gave $450,000 to support the work of Roy Kishony, PhD, Associate Professor of Systems Biology. This gift will help Kishony build a novel theoretical and experimental framework that connects extremely small-scale observations of properties of individual microbial species with large-scale observations of the behavior of microbial communities, both natural and artificial. This work may offer insight into the functioning of soil communities, and help researchers understand general principles underlying the evolution and maintenance of biodiversity. The McDonnell Foundation “was established to ‘improve the quality of life,’ and does so by contributing to the generation of new knowledge through its support of research and scholarship.”

The Cancer Research Institute, Inc. (CRI) gave $450,000 to support the work of Glenn Dranoff, MD, Associate Professor of Medicine. These funds will advance Dranoff’s studies into the molecular and cellular mechanisms underlying the generation of anti-tumor immunity. The lab has demonstrated that vaccination with irradiated tumor cells stimulates potent, specific, and long-lasting anti-tumor immunity in multiple tumor model systems. CRI, “a vital force in the advancement of new immune-based approaches to cancer treatment, control, and prevention, is dedicated exclusively to the support and coordination of laboratory and clinical efforts that will lead to the immunological treatment, control, and prevention cancer.”

The American Asthma Foundation Research Program (AAFRP) made a gift of $450,000 to support the research of Adrian Salic, PhD, Assistant Professor of Cell Biology. AAFRP supports highly innovative research that advances their mission to “develop important new pathways of investigation in basic research regarding asthma.” Salic discovered a method by which molecules similar to platelet-activating factor (PAF) can be observed under a microscope within living cells. He is refining his technique to detect PAF molecules and track their movement in living cells under various conditions in order to identify the genes that control PAF to promote inflammation. Each gene he identifies is a potential therapeutic target for asthma.

“As a professor of microbiology and the former director of the Independent Studies Program at the University of Rochester School of Medicine, I know how critical it is to support talented young faculty members at that stage in their career,” Morgan says. “It’s a joy to know that my support has helped make their subsequent contributions in teaching and research possible.”

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Industry leader’s gift supports mission critical work “

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Board of Fellows Chair Beck Gilbert is a strong supporter of medical education at Harvard Medical School.

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arvard Medical School is number one in the country, probably the world,” says Beck Gilbert, founding President and CEO of Field Point Capital Management Company and chair of the Harvard Medical School Board of Fellows. His gifts totaling $500,000 in 2009 were made to support the School and Dean Flier in a variety of initiatives, including student financial aid and the hiring of new faculty. A firm believer in the incorporation of innovative technology into medical education, Gilbert has been a big supporter of the human patient simulator, a life-sized computer-controlled mannequin “patient” used to teach medical students. A portion of his gift will also advance cutting-edge Alzheimer’s disease research. In his two years as chair, Gilbert has spread the School’s message to many leaders in industry and medicine. “I really want people to understand what HMS is all about.” His commitment to the School, he says, underscores his giving. “You know it’s mission critical. We don’t want to wait. It’s very important to step up to the plate.”

“You know it’s mission critical.” —Beckwith Gilbert

Giving back to the community while honoring the past Robert Zufall, MD ’47, and his wife, Kathryn, say they feel fortunate to be in a position to make an impact in the world. Their gift of $100,000 to support financial aid at Harvard Medical School is just one of the many contributions they have made to improve people’s lives. They also founded a clinic 20 years ago to provide primary care for an underserved, mostly Hispanic community in Dover, New Jersey near where they live.

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Trusted and true: annual gifts provide solid foundation

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nnual giving is essential to supporting the school’s ongoing needs, whether it is to offer financial aid to deserving students, hire new faculty, or maintain world-class laboratories and teaching facilities. At HMS, we are fortunate for the generosity of thousands of annual donors, whose continual commitment to the School’s mission makes our everyday work here possible. In fiscal year 2009, annual donors gave more than $4.2 million.

Among our annual giving donors are those who give to the Alumni Fund. Harvard Medical School boasts more than 10,000 living alumni, all leaders in their chosen fields of medicine or other professional endeavors. HMS accepts only the best students, regardless of their financial situations. Therefore, robust scholarship and financial aid programs are fundamental to ensuring the success of our students. The Alumni Fund supports student scholarship, thus alumni giving plays a key role in many students’ lives and careers.

Edward Hundert, Class Agent and Reunion Co-Chair for the Class of 1984, presents Dean Jeffrey Flier, MD, with his class’s 25th Reunion gift.

“The future of our profession is our current and future students,” says Mark Hughes, MD ’86, chair of the Alumni Fund. “If we want HMS to continue to attract the very best candidates and for our School’s future to be as strong as its past, we must offer viable financial aid packages.”

Annual Fund donors who make gifts of $2,000 or more are invited to become members of the Dean’s Council. Benefits of membership in the Dean’s Council include recognition in the annual Honor Roll of Donors, invitations to special events, and more.

Reunion gifts—those made by alumni returning to the School for their reunions—are a key contributor to the Alumni Fund. In 2009, 12 classes enjoyed their HMS reunions, with the Class of 1984, celebrating its 25th, the Class of 1969, celebrating its 40th, and the Class of 1959, celebrating its 50th reunion , taking the lead in reunion giving.

In 2009, Dean’s Council’s members gave more than $3,275,000, 75 percent of the total Annual Fund. To learn more about how you can make a gift to HMS, join an HMS giving society, and more, please contact Shaké Sulikyan, Director of Annual Giving, at 617-384-8454 or visit us online at give. hms.harvard.edu.

Also solid annual giving supporters are the members of the Board of Fellows, a powerful group of leaders in medicine, health care policy, and industry and a valued resource of advice and guidance for Dean Jeffrey Flier, MD. In 2009, Board of Fellows members, with key leadership from Chair Beckwith Gilbert, advanced significantly the Annual Fund’s ability to support the Dean’s initiatives.

“We have a little more money than we really need,” says Robert. “It’s more satisfying to give than to buy a yacht.” Robert says he was motivated to give to HMS out of his nostalgia and close ties to his own class of 1947. “There is a close bond,” he says. He also believes in the future: “The education of doctors who will go on to do good things in the world is important.”

“The future of our profession is our current and future students. If we want HMS to continue to attract the very best candidates and for our School’s future to be as strong as its past, we must offer viable financial aid packages.” —Mark Hughes, MD ’86

“The education of doctors who will go on to do good things in the world is important.” —Robert Zufall, MD ’47 corporate and and foundation foundation gifts gifts $250,0000 $250,0000 –– $999,999 $999,999 corporate

The Damon Runyon Cancer Research Foundation gave $420,000 to support the work of Simon Jenni, PhD, in the Laboratory of Structural Cell Biology. These funds will further Jenni’s studies of the structure of kinetochores, protein complexes that mediate the segregation of chromosomes during cell division. Discrepancies in the distribution of chromosomes in divided cells occur in many cancers; therefore, this research will identify potential avenues for anticancer therapies. The Damon Runyon Foundation selects “the most brilliant, early career scientists and provides them with funding to pursue innovative cancer research.” These “emerging leaders have great potential to achieve breakthroughs in how we diagnose, treat and prevent cancer.”

The Howard Hughes Medical Institute (HHMI) made a gift of $418,000 to support training fellowships for medical students at Harvard, overseen by Gordon Strewler, MD, Professor of Medicine. HHMI, one of the largest private funding organizations for biological and medical research in the U.S., “invests in the work, training, and education of the nation’s most creative and promising scientists.” Supported by HHMI, medical, dental and veterinary students spend a year in a laboratory to hone their science skills to prepare them for a career in research.

The Juvenile Diabetes Research Foundation International (JDRFI) made a gift of $412,271 to support the study of autoimmunity and diabetes using protein microarrays at Harvard’s Institute of Proteomics. The Institute’s research program will apply these funds to use new high-throughput technologies to understand the roles of all the proteins made in the human body in order to identify disease targets for type 1 diabetes. The mission of JDRF is “to find a cure for diabetes and its complications through the support of research.”

The Program in Cellular and Molecular Medicine and The Immune Disease Institute (PCMM/IDI) gave $402,523 to support the establishment of the Fred Rosen Professorship in Pediatrics at HMS, the Immune Disease Institute, and Children’s Hospital. Klaus Rajewsky, PhD, is the chair’s first incumbent. This Professorship is in honor of the late Rosen’s investigation of primary immune deficiencies in children and his major discoveries, particularly the pioneering development of intravenous gamma globulin therapy. A non-profit corporation academically affiliated with HMS, PCMM/IDI is a non-profit research institution recognized worldwide for its discoveries that increase the body’s ability to fight disease and to heal.

As part of their New Scholar Award in Aging, The Ellison Medical Foundation (EMF) gave $400,000 to support the work of Marcia Haigis, PhD, Assistant Professor of Pathology. This award will fund her research into fat metabolism and aging. Haigis’s project will investigate the regulation of lipid metabolism by the gene SIRT4 during aging and metabolic dysfunction. These studies may lead to novel therapeutic strategies and insights into the nature of metabolic diseases that occur as part of the normal aging process. EMF “supports basic biomedical research on aging relevant to understanding lifespan development processes and age-related diseases and disabilities.”

Gifts made in honor of alumni class reunions are the backbone of the Alumni Fund and are essential in supporting current and future students at HMS. The Reunion Gift Committee volunteers are fundamental to this effort. The 2009 reunion giving volunteers were:

CLASS OF ’59 Arthur Herbst Bert Litwin Charles Epstein Ira Marks (class agent) John Urquhart Paul Friedman Robert Adelstein Robert Blacklow

Curt Freed Sharon Murphy

CLASS OF ’69 Benjamin Cohen George Thibault (class agent) Bryan Arling Robert Mayer Howard Snyder Henry Chang Michael Gimbrone Stephen Hall Joseph Silvio Michael Mitchell William Seaman Steven Kanner

CLASS OF ’99 Elissa Blum Rottenberg (class agent)

CLASS OF ’84 Anuala Jayasuriya Erik Gaensler Nadine M. Tung Sally McNagny Redmond P. Burke (class agent)

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Clinical professorships make the grade

Slater professorship, Massachusetts General Hospital Combined gifts from Shirley Slater, Richard Slater, and Mr. and Mrs. Kenneth Z. Slater, along with gifts from past and present patients and families of Maurizio Fava, MD, Vice Chair of the Department of Psychiatry at Massachusetts General Hospital, have created the Slater Family Professorship in Psychiatry in the Field of Depression Studies at Harvard Medical School. Fava, whose research at MGH focuses on depression studies and whose clinical interests focus on depressive disorders and psychopharmacology, is the first incumbent. Smith professorship, Beth Israel Deaconess Hospital Richard and Susan Smith have established the Richard and Susan Smith Professorship in the Field of Cardiovascular Diseases at Harvard

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Endowed Naming Opportunities

A Strategy for Success

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arvard Medicine is composed of Harvard Medical School and 17 affiliated first-class hospitals and research institutions. Faculty at each of these affiliates hold HMS titles; many hold the additional distinction of an endowed named professorship. These coveted positions are awarded to faculty who are known experts in their fields and who continue to make major contributions to clinical medicine and research as well as to teaching and medical education. The generosity of numerous individuals have made possible many endowed professorships at Harvard Medical School; below are those that launched in 2009.

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Medical School. The first incumbent will be named from Beth Israel Deaconess Hospital.

Manton professorship, Children’s Hospital Boston The Manton Family Foundation established the Sir Edwin and Lady Manton Professorship in Pediatrics in the field of Genetics at Harvard Medical School. Alan H. Beggs, PhD, from Children’s Hospital Boston has been named the first incumbent. Begg’s research is focused on a better understanding of inherited disorders of muscle function by identifying and characterizing new muscle-specific genes and proteins. Linde professorship, Dana-Farber Cancer Institute The late Edward Linde, his wife, Joyce, and their children Karen, Doug, Jeff, and Carol, established the Linde Family Professorship in the field of Medical Oncology. Barrett Rollins, MD, PhD, Chief Scientific Officer at Dana-Farber Cancer Institute, is the first incumbent. Rollins’s lab focuses on the movement around the body of white blood cells, the first line of defense in the body’s immune system and the chemical factors that spur them into action. Rollins’s research aims to understand how the body can better defend itself against invaders, including cancerous tumors, or launch an attack against them.

A gift annuity supports the school and a plan for retirement Mark McMahon, MD ’86, at age 48, is on the younger side of those who make planned gifts to HMS. But, he says, when he looked at his retirement plan a few years ago and became worried about the market. A deferred gift annuity seemed a smart idea. In fiscal year 2009, he added another $100,000.

Harvard Medical School is a world leader in medical education, health care policy, global health, and biomedical research. The examples are many: raising a respected voice in the current national health care debate; providing a force on the ground in Haiti following the devastating earthquake there in January; graduating the nation’s best doctors; and producing Nobel Prize winning research. Dean Jeffrey Flier’s strategic plan is geared toward advancing HMS’s standard of excellence and international leadership in key areas. Knowledge of Disease Harvard Medical School is home to the largest community of biomedical researchers in the world. Through robust departments in the basic and social sciences as well as expertise in areas such as bioengineering, stem cell and regenerative biology, therapeutic discovery and more, Harvard Medical School is poised to make great breakthroughs in the most vexing diseases of our time, including cancer, Alzheimer’s disease and autism, as well as diabetes, mental illness, muscular dystrophies and more. Health around the World Harvard Medical School is committed to improving the health of people around the world, from villagers in the poorest, most remote communities of central Africa to those living in western urban metropolises. Whether it is developing ways to improve the delivery of medical care in Rwanda or changing U.S. national health care policy, HMS’s key priority areas of global health and social science and the biology and social impact of aging will enhance and continue HMS global leadership.

Fellowship Scholarship Financial Aid Teaching Research Technology All other Current Use Funds

75,000 50,000 25,000 25,000 25,000 25,000 25,000

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Harvard Institute of Medicine

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New Research Building Amphitheatre Lecture Hall Rotunda Courtyard Café Zen Garden Lobby and Promenade Academic Entryway Conference Center Entryway Breakout Room Corridor Lounge Amphitheatre Chair

Several areas and buildings throughout the Harvard Medical School Quadrangle and in the New Research Building are available for naming. Among them are:

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corporate and and foundation foundation gifts gifts $250,0000 $250,0000 –– $999,999 $999,999 corporate

The Foundation for Retinal Research made a gift of $300,000 to support the work of Constance Cepko, PhD, Professor of Genetics and Ophthamology. These funds will advance Cepko’s work uncovering the mechanisms that direct development of the central nervous system, specifically the production of photoreceptor cells by Müller glia. Focused on studies of the retina, researchers use genomics approaches to systematically examine gene expression over time during murine retinal development. The Foundation for Retinal Research “is committed to finding treatments and cures for retinal degenerative diseases and supporting the lives of affected families.”



Your partnership with us to end human suffering caused by disease is creating the future of medicine here and around the globe. There are many ways to support Harvard Medical School. To discuss the best way for you, please contact Christopher Painter, Executive Director of Individual Giving, at (617) 384-8462, [email protected]

“The earlier I give, the better my return at retirement.” —Mark McMahon, MD ’86

Project A.L.S. gave $300,000 to support the work of Adrian Ivinson, PhD, Founding Director of the Harvard NeuroDiscovery Center, which is advancing the search for cures for neurodegenerative diseases. These funds will help the Center to accelerate the pace of progress from scientific discoveries to meaningful patient treatments for these devastating diseases, specifically amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease. The mission of Project A.L.S. is “to recruit the world’s best research scientists and clinicians to work together toward an understanding of and the first effective treatments for ALS.”

Current Use Naming Opportunities

Space Naming Opportunities

He is also happy to be supporting student scholarships with is gift: “I look at the scientific research being done to solve disease and my hope is that these are the people who will play a role in discovery or will be clinicians alleviating disease.”

The Muscular Dystrophy Association (MDA) gave $343,151 to support the work of Marcia Haigis, PhD, Assistant Professor of Pathology, and the Paul Glenn Laboratories for the Biological Mechanisms of Aging. This gift will enable researchers to further research into the role mitochondria play in mammalian aging and disease, as mitochondrial dysfunction has been implicated in aging, neurodegeneration and metabolic diseases. Specifically, these funds will advance research on the regulation of mitochondria by SIRT3, a protein located in the mitochondrial matrix. MDA “is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research.”

$ 4,000,000 3,300,000 2,200,000 2,000,000 1,750,000 1,000,000 500,000 250,000 100,000 100,000 100,000 25,000

Leaders in Medicine The medical education curriculum developed at Harvard Medical School serves as a national model. Continually ranked the best in the country by U.S. News and World Report, Harvard Medical School attracts the most gifted students and graduates the most sought after doctors. Alumni become specialists in their fields, advise presidents, shape national policy, win Nobel Prizes and more.

“Harvard Medicine has always been a magnet for curious, creative individuals who are encouraged and supported to pursue ambitious research and innovative teaching and who keep the pipeline of scientific excellence flowing.” —Jeffrey Flier, MD, Dean, Faculty of Medicine

“The annuity is attractive, especially nowadays when I am concerned about my 401K,” says McMahon. “I can contribute to HMS, take a tax deduction, and the earlier I give, the better my return at retirement.”

Senior Professorship Clinical Professorship Associate Professorship Librarianship Academy Professorship Dean’s Initiative Fund Fellowship Scholarship Financial Aid Fund Teaching Fund Research Fund Book Fund

The Foundation Fighting Blindness (FFB) gave $300,000 to support the work of Constance Cepko, PhD, Professor of Genetics and Ophthamology. These funds will allow Cepko to further her investigation into the production of photoreceptor cells by Müller glia. Cepko’s lab researches the mechanisms of the development of different retinal cell types and the pathological loss of photoreceptors, devising genetic procedures for restoring retinal function. The mission of FFB “is to drive the research that will provide preventions, treatments and cures for people affected by retinitis pigmentosa, macular degeneration, Usher syndrome, and the entire spectrum of retinal degenerative diseases.”

The Entertainment Industry Foundation (EIF) made a gift of $300,000 to support the work of Joan Brugge, PhD, Chair, Department of Cell Biology. This gift will fund the work of a translational breast cancer research laboratory, where Brugge will advance her research into creating three-dimensional biological structures resembling the glands of the breast. These structures permit Brugge and her colleagues to learn new ways to block the abnormal behavior of cells, including cancer cells and cancer stem cells.

Tosteson Medical Education Center Classroom Conference Room Tutorial Room Faculty Research Office Graduate Fellows Office

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Benefactor partners in discovery

Paul Farmer, MD ’90, chair of the Department of Global Health and Social Medicine and co-founder of Partners in Health, led a symposium in February to talk about the Harvard Medical School response to help the victims of the Haiti earthquake in January. Farmer is recognized world-wide for his work to develop sustainable health care delivery systems in Haiti and other poor regions around the globe.

401 Park Drive Suite 22 West Boston, MA 02215

Roger Sametz Sametz Blackstone Associates 40 West Newton Street Blackstone Square Boston, MA 02118

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Benefactor

to create and nurture a diverse community of the best people committed to leadership in alleviating human suffering caused by disease