Cancer Research

Cancer Research

Cancer Research A Journal AmericanAssociation Association for Research A Journal of of thethe American forCancer Cancer Research Volume 69 • Number 1...

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Cancer Research

A Journal AmericanAssociation Association for Research A Journal of of thethe American forCancer Cancer Research Volume 69 • Number 17 Point-Counterpoint Reviews Genomic Alterations in Tumor Stroma. Charis Eng, Gustavo Leone, Mohammed S. Orloff, and Michael C. Ostrowski ........................................6759 Clonal Mutations in the Cancer-Associated Fibroblasts: The Case against Genetic Coevolution. Ian Campbell, Kornelia Polyak, and Izhak Haviv .................................................................................6765

September 1, 2009 • Pages 6759–7130 Clinical Research Immunodetection of DNA Repair Endonuclease ERCC1-XPF in Human Tissue. Nikhil R. Bhagwat, Vera Y. Roginskaya, Marie B. Acquafondata, Rajiv Dhir, Richard D. Wood, and Laura J. Niedernhofer .............................................................................6831

Endocrinology Meeting Report 2009 Biospecimen Research Network Symposium: Advancing Cancer Research through Biospecimen Science. Helen M. Moore, Carolyn C. Compton, Mark D. Lim, Jimmie Vaught, Katerina N. Christiansen, and Joe Alper...........................................................................................6770

RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer. Cory Iverson, Gary Larson, Chon Lai, Li-Tain Yeh, Claudia Dadson, Paul Weingarten, Todd Appleby, Todd Vo, Andreas Maderna, Jean-Michel Vernier, Robert Hamatake, Jeffrey N. Miner, and Barry Quart ...........................................................6839

Epidemiology Cell, Tumor, and Stem Cell Biology Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation. Suzanne C. Brady, Mathew L. Coleman, June Munro, Stephan M. Feller, Nicolas A. Morrice, and Michael F. Olson .....................................................................................6773 Identification of a Protein, G0S2, That Lacks Bcl-2 Homology Domains and Interacts with and Antagonizes Bcl-2. Christian Welch, Manas K. Santra, Wissal El-Assaad, Xiaochun Zhu, Wade E. Huber, Richard A. Keys, Jose G. Teodoro, and Michael R. Green..................................................................................6782 A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion. Hui-Wen Lo, Hu Zhu, Xinyu Cao, Amy Aldrich, and Francis Ali-Osman ....................................................6790 Circulating Galectin-3 Promotes Metastasis by Modifying MUC1 Localization on Cancer Cell Surface. Qicheng Zhao, Xiuli Guo, Gerard B. Nash, Philip C. Stone, John Hilkens, Jonathan M. Rhodes, and Lu-Gang Yu .............................................................................................6799 Ectopic Runx2 Expression in Mammary Epithelial Cells Disrupts Formation of Normal Acini Structure: Implications for Breast Cancer Progression. Jitesh Pratap, Karen M. Imbalzano, Jean M. Underwood, Nathalie Cohet, Karthiga Gokul, Jacqueline Akech, Andre J. van Wijnen, Janet L. Stein, Anthony N. Imbalzano, Jeffrey A. Nickerson, Jane B. Lian, and Gary S. Stein.........................6807 Functional Significance of Secreted Frizzled-Related Protein 1 in Metastatic Renal Cell Carcinomas. Sharanjot Saini, Jan Liu, Soichiro Yamamura, Shahana Majid, Kazumori Kawakami, Hiroshi Hirata, and Rajvir Dahiya ......................................................6815 Identification of a Stat3-Dependent Transcription Regulatory Network Involved in Metastatic Progression. Jill J. Ranger, David E. Levy, Solmaz Shahalizadeh, Michael Hallett, and William J. Muller.....................................................................................6823

The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans. Nancy L. Saccone, Jen C. Wang, Naomi Breslau, Eric O. Johnson, Dorothy Hatsukami, Scott F. Saccone, Richard A. Grucza, Lingwei Sun, Weimin Duan, John Budde, Robert C. Culverhouse, Louis Fox, Anthony L. Hinrichs, Joseph Henry Steinbach, Meng Wu, John P. Rice, Alison M. Goate, and Laura J. Bierut .........................................................................................6848 Polymorphisms in DNA Repair Genes, Smoking, and Bladder Cancer Risk: Findings from the International Consortium of Bladder Cancer. Mariana C. Stern, Jie Lin, Jonine D. Figueroa, Karl T. Kelsey, Anne E. Kiltie, Jian-Min Yuan, Giuseppe Matullo, Tony Fletcher, Simone Benhamou, Jack A. Taylor, Donatella Placidi, Zuo-Feng Zhang, Gunnar Steineck, Nathaniel Rothman, Manolis Kogevinas, Debra Silverman, Nuria Malats, Stephen Chanock, Xifeng Wu, Margaret R. Karagas, Angeline S. Andrew, Heather H. Nelson, D. Timothy Bishop, Sei Chung Sak, Ananya Choudhury, Jennifer H. Barrett, Faye Elliot, Román Corral, Amit D. Joshi, Manuela Gago-Dominguez, Victoria K. Cortessis, Yong-Bing Xiang, Yu-Tang Gao, Paolo Vineis, Carlotta Sacerdote, Simonetta Guarrera, Silvia Polidoro, Alessandra Allione, Eugen Gurzau, Kvetoslava Koppova, Rajiv Kumar, Peter Rudnai, Stefano Porru, Angela Carta, Marcello Campagna, Cecilia Arici, Sung Shim Lani Park, and Montserrat Garcia-Closas for the International Consortium of Bladder Cancer .............................................6857 Adjuvant Hormonal Therapy for Breast Cancer and Risk of Hormone Receptor–Specific Subtypes of Contralateral Breast Cancer. Christopher I. Li, Janet R. Daling, Peggy L. Porter, Mei-Tzu C. Tang, and Kathleen E. Malone .....................................................................6865

Experimental Therapeutics, Molecular Targets, and Chemical Biology Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL. Li Liu, James Greger, Hong Shi, Yuan Liu, Joel Greshock, Roland Annan, Wendy Halsey, Ganesh M. Sathe, Anne-Marie Martin, and Tona M. Gilmer ..............................................6871

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Contents (Continued) Intracellular ␤-Tubulin/Chaperonin Containing TCP1-␤ Complex Serves as a Novel Chemotherapeutic Target against Drug-Resistant Tumors. Yuan-Feng Lin, Wen-Ping Tsai, Hon-Ge Liu, and Po-Huang Liang ..............................................................6879 Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients. Kan V. Lu, Shaojun Zhu, Anna Cvrljevic, Tiffany T. Huang, Shawn Sarkaria, David Ahkavan, Julie Dang, Eduard B. Dinca, Seema B. Plaisier, Isaac Oderberg, Yohan Lee, Zugen Chen, Jeremy S. Caldwell, Yongmin Xie, Joseph A. Loo, David Seligson, Arnab Chakravari, Francis Y. Lee, Roberto Weinmann, Timothy F. Cloughesy, Stanley F. Nelson, Gabriele Bergers, Thomas Graeber, Frank B. Furnari, C. David James, Webster K. Cavenee, Terrance G. Johns, and Paul S. Mischel .................................................6889 Human Multiple Myeloma Cells Are Sensitized to Topoisomerase II Inhibitors by CRM1 Inhibition. Joel G. Turner, Douglas C. Marchion, Jana L. Dawson, Michael F. Emmons, Lori A. Hazlehurst, Peter Washausen, and Daniel M. Sullivan...................................................................................6899 Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77. Cristiano Ferlini, Lucia Cicchillitti, Giuseppina Raspaglio, Silvia Bartollino, Samanta Cimitan, Carlo Bertucci, Simona Mozzetti, Daniela Gallo, Marco Persico, Caterina Fattorusso, Giuseppe Campiani, and Giovanni Scambia ................................................................................6906 Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts. Dmitri Kapitonov, Jeremy C. Allegood, Clint Mitchell, Nitai C. Hait, Jorge A. Almenara, Jeffrey K. Adams, Robert E. Zipkin, Paul Dent, Tomasz Kordula, Sheldon Milstien, and Sarah Spiegel.............6915 c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol–Treated Ewing Sarcoma Cells. Séverine Lorin, Amélie Borges, Lisandra Ribeiro Dos Santos, Sylvie Souquère, Gérard Pierron, Kevin M. Ryan, Patrice Codogno, and Mojgan Djavaheri-Mergny ...............................................................6924 Preclinical Evaluation of Novel Glutamate-Urea-Lysine Analogues That Target Prostate-Specific Membrane Antigen as Molecular Imaging Pharmaceuticals for Prostate Cancer. Shawn M. Hillier, Kevin P. Maresca, Frank J. Femia, John C. Marquis, Catherine A. Foss, Nghi Nguyen, Craig N. Zimmerman, John A. Barrett, William C. Eckelman, Martin G. Pomper, John L. Joyal, and John W. Babich.................................6932 Inhibitors of Deacetylases Suppress Oncogenic KIT Signaling, Acetylate HSP90, and Induce Apoptosis in Gastrointestinal Stromal Tumors. Thomas Mühlenberg, Yixiang Zhang, Andrew J. Wagner, Florian Grabellus, James Bradner, Georg Taeger, Hauke Lang, Takahiro Taguchi, Martin Schuler, Jonathan A. Fletcher, and Sebastian Bauer ......................................................................................6941 Blockade of Wnt Signaling Inhibits Angiogenesis and Tumor Growth in Hepatocellular Carcinoma. Jie Hu, Aiwen Dong, Veronica Fernandez-Ruiz, Juanjuan Shan, Milosz Kawa, Eduardo Martínez-Ansó, Jesus Prieto, and Cheng Qian ........................6951

Immunology Classification of Chemotherapeutic Agents Based on Their Differential In vitro Effects on Dendritic Cells. Hiroaki Tanaka, Hironori Matsushima, Norikatsu Mizumoto, and Akira Takashima .............................................................................6978 Dual Therapeutic Efficacy of Vinblastine as a Unique Chemotherapeutic Agent Capable of Inducing Dendritic Cell Maturation. Hiroaki Tanaka, Hironori Matsushima, Akiko Nishibu, Björn E. Clausen, and Akira Takashima ......................6987 Heat Shock Protein 90 Inhibitor 17-Dimethylaminoethylamino-17Demethoxygeldanamycin Enhances EphA2ⴙ Tumor Cell Recognition by Specific CD8ⴙ T Cells. Mayumi Kawabe, Maja Mandic, Jennifer L. Taylor, Cecilia A. Vasquez, Amy K. Wesa, Leonard M. Neckers, and Walter J. Storkus .....................................................................................6995

Molecular Biology, Pathobiology, and Genetics Mutagenicity and Potential Carcinogenicity of Thiopurine Treatment in Patients with Inflammatory Bowel Disease. Truc Nguyen, Pamela M. Vacek, Patrick O’Neill, Richard B. Colletti, and Barry A. Finette ....................................................................................7004 MUC1-C Oncoprotein Functions as a Direct Activator of the Nuclear Factor-␬B p65 Transcription Factor. Rehan Ahmad, Deepak Raina, Maya Datt Joshi, Takeshi Kawano, Jian Ren, Surender Kharbanda, and Donald Kufe...................................................7013 Human Papillomavirus 16 E7 Oncoprotein Attenuates DNA Damage Checkpoint Control by Increasing the Proteolytic Turnover of Claspin. Nicole Spardy, Kathryn Covella, Elliot Cha, Elizabeth E. Hoskins, Susanne I. Wells, Anette Duensing, and Stefan Duensing ...................................................................................7022 Multimodal Assessment of Protein Functional Deficiency Supports Pathogenicity of BRCA1 p.V1688del. Arcangela De Nicolo, Emilio Parisini, Quan Zhong, Maurizia Dalla Palma, Kathryn A. Stoeckert, Susan M. Domchek, Katherine L. Nathanson, Maria A. Caligo, Marc Vidal, Michael E. Cusick, and Judy E. Garber................................7030 Functional Significance of Cytochrome P450 1B1 in Endometrial Carcinogenesis. Sharanjot Saini, Hiroshi Hirata, Shahana Majid, and Rajvir Dahiya.........................................................................................7038 TGFBR1 Haplotypes and Risk of Non–Small-Cell Lung Cancer. Zhe Lei, Reng-Yun Liu, Jun Zhao, Zeyi Liu, Xiefang Jiang, Weiming You, Xiao-Feng Chen, Xia Liu, Kui Zhang, Boris Pasche, and Hong-Tao Zhang...................................................................................7046

Proteolytic Cleavage of Protein Tyrosine Phosphatase ␮ Regulates Glioblastoma Cell Migration. Adam M. Burgoyne, Polly J. Phillips-Mason, Susan M. Burden-Gulley, Shenandoah Robinson, Andrew E. Sloan, Robert H. Miller, and Susann M. Brady-Kalnay ...........................................6960

Comprehensive Molecular Analysis of Mismatch Repair Gene Defects in Suspected Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Cases. James Mueller, Isabella Gazzoli, Prathap Bandipalliam, Judy E. Garber, Sapna Syngal, and Richard D. Kolodner ............................................................................7053

Distinct Concentration-Dependent Effects of the Polo-like Kinase 1–Specific Inhibitor GSK461364A, Including Differential Effect on Apoptosis. Aidan G. Gilmartin, Maureen R. Bleam, Mark C. Richter, Symon G. Erskine, Ryan G. Kruger, Lenore Madden, Daniel F. Hassler, Gary K. Smith, Richard R. Gontarek, Mary P. Courtney, David Sutton, Melody A. Diamond, Jeffrey R. Jackson, and Sylvie G. Laquerre ................6969

Kisspeptin-10, a KISS1-Derived Decapeptide, Inhibits Tumor Angiogenesis by Suppressing Sp1-Mediated VEGF Expression and FAK/Rho GTPase Activation. Sung-Gook Cho, Zhengfang Yi, Xiufeng Pang, Tingfang Yi, Ying Wang, Jian Luo, Zirong Wu, Dali Li, and Mingyao Liu ............................................................................7062

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Contents (Continued) MicroRNA Expression, Chromosomal Alterations, and Immunoglobulin Variable Heavy Chain Hypermutations in Mantle Cell Lymphomas. Alba Navarro, Sílvia Be`a, Verónica Fernández, Miriam Prieto, Itziar Salaverria, Pedro Jares, Elena Hartmann, Anna Mozos, Armando López-Guillermo, Neus Villamor, Dolors Colomer, Xavier Puig, German Ott, Francesc Solé, Sergi Serrano, Andreas Rosenwald, Elías Campo, and Luis Hernández ......................7071 Chromobox Protein Homologue 7 Protein, with Decreased Expression in Human Carcinomas, Positively Regulates E-Cadherin Expression by Interacting with the Histone Deacetylase 2 Protein. Antonella Federico, Pierlorenzo Pallante, Mimma Bianco, Angelo Ferraro, Francesco Esposito, Maria Monti, Marianna Cozzolino, Simona Keller, Monica Fedele, Vincenza Leone, Giancarlo Troncone, Lorenzo Chiariotti, Piero Pucci, and Alfredo Fusco ...................................................................................7079

Inhibition of Activator Protein-1 by Sulforaphane Involves Interaction with Cysteine in the cFos DNA-Binding Domain: Implications for Chemoprevention of UVB-Induced Skin Cancer. Sally E. Dickinson, Tania F. Melton, Erik R. Olson, Jian Zhang, Kathylynn Saboda, and G. Timothy Bowden .....................................7103

Systems Biology and Emerging Technologies The Role of Transforming Growth Factor-␤–Mediated Tumor-Stroma Interactions in Prostate Cancer Progression: An Integrative Approach. David Basanta, Douglas W. Strand, Ralf B. Lukner, Omar E. Franco, David E. Cliffel, Gustavo E. Ayala, Simon W. Hayward, and Alexander R.A. Anderson ....................................7111

Tumor Microenvironment Prevention Chemopreventive Effects of Gefitinib on Nonsmoking-Related Lung Tumorigenesis in Activating Epidermal Growth Factor Receptor Transgenic Mice. Kadoaki Ohashi, Nagio Takigawa, Masahiro Osawa, Eiki Ichihara, Hiromasa Takeda, Toshio Kubo, Seiki Hirano, Tadashi Yoshino, Minoru Takata, Mitsune Tanimoto, and Katsuyuki Kiura ...............................................................................7088

Ovarian Cancer Cell Detachment and Multicellular Aggregate Formation Are Regulated by Membrane Type 1 Matrix Metalloproteinase: A Potential Role in I.p. Metastatic Dissemination. Natalie M. Moss, Maria V. Barbolina, Yueying Liu, Limin Sun, Hidayatullah G. Munshi, and M. Sharon Stack ......................7121

Corrections Dietary Feeding of Dibenzoylmethane Inhibits Prostate Cancer in Transgenic Adenocarcinoma of the Mouse Prostate Model. Tin Oo Khor, Siwang Yu, Avanthika Barve, Xingpei Hao, Jin-Liern Hong, Wen Lin, Barbara Foster, Mou-Tuan Huang, Harold L. Newmark, and Ah-Ng Kong................................................................................7096

Correction: Article on Proteasome Inhibition and Regression of Ph+ Leukemia ...................................................................................7130 Correction: Article on E2F7 in SCC....................................................7130

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69 (17) Cancer Res 2009;69:6759-7130.

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