Contents - Molecular Cancer Research

Contents - Molecular Cancer Research

Molecular Cancer Research Contents A Journal of the Molecular and Cellular Biology of Cancer October 2012  Volume 10  Number 10 1319 Highlights ...

291KB Sizes 0 Downloads 6 Views

Molecular Cancer Research

Contents

A Journal of the Molecular and Cellular Biology of Cancer

October 2012  Volume 10  Number 10 1319

Highlights of This Issue 1241

REVIEWS 1243

A Novel Function of YWHAZ/b-Catenin Axis in Promoting Epithelial– Mesenchymal Transition and Lung Cancer Metastasis Ching-Hsien Chen, Show-Mei Chuang, Meng-Fang Yang, Jiunn-Wang Liao, Sung-Liang Yu, and Jeremy J.W. Chen

N-myc and Noncoding RNAs in Neuroblastoma Jochen Buechner and Christer Einvik

1254

Revisiting the Complexity of the Ovarian Cancer Microenvironment— Clinical Implications for Treatment Strategies

CANCER GENES AND GENOMICS 1332

Natasha Musrap and Eleftherios P. Diamandis

1265

GAB2—a Scaffolding Protein in Cancer

Marcos R.H. Estecio, Juan Gallegos, Mhair Dekmezian, Yue Lu, Shoudan Liang, and Jean-Pierre J. Issa

Sarah J. Adams, Iraz T. Aydin, and Julide T. Celebi

ANGIOGENESIS, METASTASIS, AND THE CELLULAR MICROENVIRONMENT 1271

CELL CYCLE, CELL DEATH, AND SENESCENCE

Role of Plasminogen Activator Inhibitor-1 in Urokinase's Paradoxical In Vivo Tumor Suppressing or Promoting Effects

1343

Yuqi Jing, Krisztina Kovacs, Vittal Kurisetty, Zhijie Jiang, Nick Tsinoremas, and Jaime R. Merchan

1282

DNA DAMAGE AND CELLULAR STRESS RESPONSES 1359

Macrophages Promote Fibroblast Growth Factor Receptor-Driven Tumor Cell Migration and Invasion in a Cxcr2-Dependent Manner Laura R. Bohrer and Kathryn L. Schwertfeger

1306

Expression of G Protein-Coupled Receptor 19 in Human Lung Cancer Cells Is Triggered by Entry into S-Phase and Supports G2–M Cell-Cycle Progression Stefan Kastner, Tilman Voss, Simon Keuerleber, Christina Gl€ ockel, Michael Freissmuth, and Wolfgang Sommergruber

Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells Catherine A. Parr-Sturgess, Claire L. Tinker, Claire A. Hart, Michael D. Brown, Noel W. Clarke, and Edward T. Parkin

1294

SINE Retrotransposons Cause Epigenetic Reprogramming of Adjacent Gene Promoters

Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance Prashanthi Javvadi, Haruhiko Makino, Amit K. Das, Yu-Fen Lin, David J. Chen, Benjamin P. Chen, and Chaitanya S. Nirodi

Regulation of Inflammatory Breast Cancer Cell Invasion through Akt1/PKBa Phosphorylation of RhoC GTPase Heather L. Lehman, Steven J. Van Laere, Cynthia M. van Golen, Peter B. Vermeulen, Luc Y. Dirix, and Kenneth L. van Golen

A Journal of the American Association for Cancer Research

iii

www.aacrjournals.org

Downloaded from mcr.aacrjournals.org on April 23, 2018. © 2012 American Association for Cancer Research.

1389

SIGNALING AND REGULATION 1369

Ah Receptor Antagonism Represses Head and Neck Tumor Cell Aggressive Phenotype

Ethan A. Kohn, Yu-an Yang, Zhijun Du, Yoshiko Nagano, Catherine M.H. Van Schyndle, Michelle A. Herrmann, Madeleine Heldman, Jin-Qiu Chen, Christina H. Stuelten, Kathleen C. Flanders, and Lalage M. Wakefield

Brett C. DiNatale, Kayla Smith, Kaarthik John, Gowdahalli Krishnegowda, Shantu G. Amin, and Gary H. Perdew

1380

Biological Responses to TGF-b in the Mammary Epithelium Show a Complex Dependency on Smad3 Gene Dosage with Important Implications for Tumor Progression

The Essential Role of Gia2 in Prostate Cancer Cell Migration Miao Zhong, Shineka Clarke, BaoHan T. Vo, and Shafiq A. Khan

ABOUT THE COVER Activation of fibroblast growth factor receptor 1 (FGFR1) in mammary epithelial cells induces recruitment of macrophages to the mammary epithelium, which contributes to FGFR1-induced tumor formation. Using 3D co-culture assays in which FGFR1 was activated specifically in mammary epithelial cells, macrophages were found to associate with the epithelial structures and induce invasion of the cells into the surrounding basement membrane matrix. Further studies demonstrated that this interaction was dependent upon increased secretion of Cxcr2-binding chemokines by macrophages following exposure to FGFR1-induced soluble factors produced by the epithelium. For details see Bohrer and Schwertfeger on page 1294.

iv

Molecular Cancer Research

Downloaded from mcr.aacrjournals.org on April 23, 2018. © 2012 American Association for Cancer Research.

10 (10) Mol Cancer Res 2012;10:1241-1399.

Updated version

E-mail alerts Reprints and Subscriptions Permissions

Access the most recent version of this article at: http://mcr.aacrjournals.org/content/10/10

Sign up to receive free email-alerts related to this article or journal. To order reprints of this article or to subscribe to the journal, contact the AACR Publications Department at [email protected] To request permission to re-use all or part of this article, use this link http://mcr.aacrjournals.org/content/10/10. Click on "Request Permissions" which will take you to the Copyright Clearance Center's (CCC) Rightslink site.

Downloaded from mcr.aacrjournals.org on April 23, 2018. © 2012 American Association for Cancer Research.