environmental and genetic factors in allergy and - Pacini Medicina

environmental and genetic factors in allergy and - Pacini Medicina

Environmental and Genetic Factors in Allergy and Clinical Immunology Proceedings of the 27th Symposium of the Collegium Internationale Allergologicum ...

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Environmental and Genetic Factors in Allergy and Clinical Immunology Proceedings of the 27th Symposium of the Collegium Internationale Allergologicum (CIA)

Editors Ronald van Ree Johannes Ring Gianni Marone

Table of contents Preface


Concept and history of the Collegium Internationale Allergologicum (CIA) J. Ring


MAST CELLS, BASOPHILS, AND EOSINOPHILS Expression of vascular endothelial growth factors and their receptors in human mast cells G. Marone, A. Detoraki, R.I. Staiano, F. Granata, G. Giannattasio, N. Prevete, A. de Paulis, D. Ribatti, A. Genovese, M. Triggiani

Suppression of normal and malignant Kit signaling in mast cells by a bi-specific antibody linking Kit with CD300a B. Berent-Maoz, I. Bachelet, A. Munitz, D. Mankuta, F. Levi- Schaffer

Idiopathic anaphylaxis in mast cell clonal disorders is potentially linked to D816V KIT-induced hyper-activation of key signaling events for mast cell activation Y. Bai, S. Iwaki, A.M. Gilfillan, D.D. Metcalfe

Induction of mast cell apoptosis – A new way to treat allergy and other mast cell associated diseases? M. Ekoff, M. Karlberg, C. Möller Westerberg, G. Nilsson

MITF and its regulation in mast cells by a pathway involving Lysyl tRNA synthetase, Hint-1 and Ap4A H. Nechushtan, N. Yannay-Cohen, I. Carmi-Levy, G. Kay, E. Razin

TRPC5/Orai1/STIM1-dependent store-operated entry of Ca regulates degranulation in a mast cell line







H.-T. Ma, Z. Peng, T. Hiragun, S. Iwaki, A. Gilfillan, M. Beaven

SNARE proteins in human mast cell degranulation: Role of SNAP23, Syntaxin-4, VAMP-7, and VAMP-8 A. Lorentz, S. Frank, L.E. Sander, S.C. Bischoff

Group IIA secreted phospholipase A2 is expressed and released by human mast cells F. Granata, S. Loffredo, G. Giannattasio, C. Calabrese, M. Testa, G. Monaco, G. Marone, M. Triggiani

Nitric oxide production and evidence for protein tyrosine nitration in mast cells Y. Sekar, T.C. Moon, T. Yoshimura, A.D. Befus

The urokinase/urokinase receptor: a novel target for the treatment of allergic disease A. de Paulis, N. Prevete, F.W. Rossi, G. Marone, N. Montuori, P. Ragno, G. Rossi

Basophils and mast cells play distinct roles in acute and chronic allergic reactions H. Karasuyama, Y. Tsujimura, K. Obata, K. Mukai, Y. Minegishi

IgE-induced activation of human basophils stimulates hypoxia-inducible factor-1α accumulation V.V. Sumbayev, B.F. Gibbs

Are basophils present in chronic urticaria lesions? M. Ferrer, M. Idoate, P. Gil, M.L. Sanz, A.P. Kaplan

Role of IgE repertoire complexity in basophil activation L.H. Christensen, J. Holm, P.A. Würtzen, N. Willumsen, K. Lund

Eosinophils: new effectors in innate immunity V. Driss, F. Legrand, M. Capron

Regulation of eosinophil functions by peroxisome-proliferator activated receptor agonists S. Ueki, M. Takeda, W. Ito, H. Kayaba, J. Chihara


45 49 55

59 63

67 71 73 79


Comparison between human neutrophils and eosinophils in matrix metalloproteinase-9 release S. Takafuji, A. Ishida, Y. Miyakuni, T. Nakagawa


T CELLS AND DENDRITIC CELLS Age related changes in regulatory T cell markers and toll-like receptor-mediated innate responses in allergic and nonallergic children S.L. Prescott, M.K. Tulic

Clonal switch to IL-10-secreting type 1 T regulatory cells in high dose allergen exposure F. Meiler, J. Zumkehr, S. Klunker, B. Rückert, D.G. Akdis, C.A. Akdis, M. Akdis

The transistor model of T-cell differentiation C.B. Schmidt-Weber, S.R. Durham

Mechanisms of direct T cell suppression by IL-10 and TGF-β S. Klunker, A. Taylor, J. Verhagen, M. Akdis, C.A. Akdis

T-cells and eosinophils are crucial in the remodeling of bronchial smooth muscle cell layer in asthma K. Solarewicz-Madejek, T.M. Basinski, M. Akdis, K. Blaser, K.F. Rabe, C.A. Akdis, M. Jutel

CD4 T cells from atopic dermatitis patients show differential expression of genes related to skin homing, proliferation and apoptosis by selective expression in the skin homing CLA+ T cell population


99 103 107



D. Hijnen, E. Nijhuis, C. Bruijnzeel-Koomen, J. van der Linden, M. de Bruijn-Weller, E. Knol

Proinflammatory dendritic cells in patients with atopic dermatitis W. Baran, A. Hänsel, M. Meurer,K. Schäkel

Induction of regulatory T cells by treatment of atopic subject tH2 cells with tolerogenic dendritic cells X. Li, A. Yang, H. Huang, X. Zhang, J. Town, B. Davis, D.W. Cockcroft, J.R. Gordon

115 119


GENETIC AND ENVIRONMENTAL FACTORS IN ALLERGIC DISORDERS Maternal protein restriction during pregnancy results in persistent alterations in lung gene expression: evidence for fetal programming of lung development M.J. Rose-Zerilli, S.T. Holgate, M.A. Hanson, C. Torrens, J.W. Holloway

Gene expression profiling after acute versus chronic allergen airway exposure reveals distinct gene clusters H.-A. Meyer, C. Heidt, M. Krokowski, A. M. Dittrich,E. Hamelmann

Early aberrant antibody responses of aeroallergen sensitised people to subclinical bacterial infection B.J. Hales, W-A Smith, P.G. Holt, M.M.H. Kusel, P.N. LeSouef, W.R. Thomas

Asthma prevention in early life by stable-derived Acinetobacter lwoffii R. Teich, P.I. Pfefferle, S. Brand, N. Blümer, M.L. Conrad, H. Garn, H. Renz

Non-typeable Haemophilus influenzae (NTHi): a cause of bronchospasm and a target for therapy in subjects with smoking-related chronic airways disease (SRCAD) R.L. Clancy, M. Dunkley, D.C. Otczyk, A.W. Cripps

Chronic IL-13 stimulation of human airway epithelial cells alters the chemokine response to rhinovirus (RV) 16 S.E. Wenzel, J.B. Trudeau, J. Gern



137 141



PATHOPHYSIOLOGY OF ALLERGIC AND INFLAMMATORY DISEASES The role of IL-25 in airways inflammation and remodelling in asthma Q. Meng, C. Fang, Y. Wang, Yongjun Liu, T.H. Lee, C.J Corrigan, S. Ying


Structure and function of human leukotriene C4 synthase, an integral membrane protein and therapeutic target in asthma A. Rinaldo-Matthis, D. Martinez Molina, A. Wetterholm, P. Nordlund, J.Z. Haeggström

Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease K. Izuhara, S. Kanaji, I. Nakao, K. Arima, A. Nakajima, H. Matsushita, S. Ohta, H. Tanaka, H. Nagai

Expression and cellular provenance of thymic stromal lymphopoietin (TSLP) and chemokines in patients with severe asthma, COPD and controls S. Ying, Q. Meng, B. O’Connor, J. Ratoff, D. Cousins, T.H. Lee, C.J. Corrigan

Protease-Activated Receptor-2 (PAR-2) activation mediates allergic sensitization to cockroach extracts M. Abel, N. Arizmendi, C. Ebeling, M. Hollenberg, H. Vliagoftis

Airways remodelling activity of the resistin-like molecule RELM-β in asthmatic airways C.J. Corrigan, C. Fang, Q. Meng, T.H. Lee, S. Ying

Immunoglobulin free light chains are present in chronic inflammatory diseases: studies in allergic and non-allergic rhinitis, multiple sclerosis and rheumatoid arthritis F.A. Redegeld, E. Breij, S.C. Berndsen, D.G. Powe, F.P. Nijkamp

Role of histamine-mediated signaling in the pathogenesis of severe malaria in mice W. Beghdadi, A. Porcherie, B.S. Schneider, H. Ohtsu, R. Peronet, M. Dy, J. Louis, J.-M. Arrang, S. Mécheri

Establishment of severe allergic asthma and dermatitis models caused by repeated application of Dermatophagoides farinae H. Nagai, N. Inagaki, K. Wakahara, H. Tanaka

Potential role for PGD2 metabolites in mast cell-mediated sensory nerve activation T.E. Taylor-Clark, M.A. McAlexander, B.J. Undem




165 169

171 175

179 183

clinical aspects of allergic disorders Anaphylaxis in patients with IgE antibodies to galactose α-1, 3-galactose, can occur on exposure to mammalian proteins (including the monoclonal antibody Cetuximab) which are glycosylated with this major xenoantigen T.A.E. Platts-Mills, H. James, S.P. Commins

Cerebral regions involved in perception and processing of histamine itch F. Pfab, M. Valet, T. Sprenger, T.R. Tölle, G.I. Athanasiadis, H. Behrendt, J. Ring, U. Darsow

Establishment of food provocation network in Japan M. Ebisawa, C. Sugizaki

191 195 199

Sensitisation to Ambrosia in Switzerland: a public health threat on the wait U. Ackermann-Liebrich, C. Schindler, P. Frei, N.M. Probst-Hensch, M. Imboden, A. Gemperli, T. Rochat, P. Schmid-Grendelmeier, A.J. Bircher; the SAPALDIA team

Relevance of mite sensitization in workers exposed to grain dust M. Raulf-Heimsoth,I. Sander, E. Zahradnik, S. Mayer, C. Fleischer, U. Meurer, Th. Brüning

Component resolved diagnosis in everyday allergy practice B.E. García, M.T. Lizaso, A.I. Tabar, S. Echechipía, M.J. Álvarez, B. Gómez, M. Anda, E. Lasa, D. Barber

Eczema herpeticum recidivans A. Wollenberg, M. Grichtmeier, H.C. Rerinck, S. Kamann

Asthma symptoms among schoolchildren in Georgia A. Gamkrelidze, M. Gotua, M. Rukhadze, T. Abramidze

203 207 211 213 215

ALLERGENS X-ray crystallography of a monoclonal antibody complex with cockroach allergen Bla g 2 and identification of putative IgE epitopes A. Pomés, M. Li, S. Wünschmann, L. Stohr, C. Kepley, E.M. King, J. Alexandratos, M.D. Chapman, A. Wlodawer, A. Gustchina


Characterization of monoclonal antibodies against Bet v 1 and their use as tools for quality assessment of recombinant Bet v 1 derivatives H. Kahlert, B. Weber, H. Fiebig, O. Cromwell

Genomics of Aspergillus fumigatus allergens R. Crameri

225 229

Identification and characterization of lentil sensitization patterns J.H. Akkerdaas, S. Santos Magadan, E.I. Finkina, T.V. Ovchinnikova, C. Summers, M. Fernandez-Rivas, A.C. Knulst, R. van Ree

Microarray of allergenic components-based diagnosis in polysensitized patients M.L. Sanz, M.J. Goikoetxea, P.M. Gamboa, G. Gastaminza, M. Fernández-Benitez, M. Ferrer

Specific IgE measurements by microchips. Theoretical considerations and a comparison between the ISAC® Chip and the ImmunoCAP® M.H. Pedersen, M. Dufva, A. Hansen, L.K. Poulsen

Interaction of the major grass pollen allergen Phl p 1 with the respiratory interphase: activation, uptake and transport A. Petersen, K. Röschmanna, C. Blumea, T. Goldmann, A.J. Ulmer, W.M. Becker

Assessment of the clinical relevance of plant-glycan specific igE by in vivo challenge with transgenic human lactoferrin expressed in rice A. Mari, P. Ooievaar-de Heer, L. Zuidmeer, E. Scala, D. Bethell, R. van Ree

Phleum pratense alone is representative of Pooideae grass species for allergen specific immunotherapy J.N. Larsen,C. Hejl, H. Ipsen, P. Adler Würtzen, N. Johansen

231 233





NOVEL PHARMACOLOGICAL AND IMMUNOLOGIC TREATMENTS OF ALLERGIC DISEASES GATA-3-specific DNAzyme – a novel approach toward asthma therapy T. Dicke, M. Wegmann, S. Sel, H. Renz, H. Garn

An IgE-based polyplex allergen gene vaccine that targets dendritic cells: a novel therapeutic approach for severe food allergy K. Zhang, A. Behnecke, A. Saxon, W. Li

Nitric oxide and ceramide pathway interaction: a new target in allergic asthma E. Masini, R. Mastroianni, C. Uliva, M.C. Vinci, E. Ragazzo, L. Cinci, G. Matuschak, D. Salvemini

The therapeutic potential of anti-mIgE antibodies S. Feichtner, G. Achatz-Straussberger, S. Lenz, R. Crameri, G. Achatz

In vitro corticosteroid treatment enhances TNF-α mediated inflammatory reactions of pulmonary microvascular endothelial cells K. Orihara, S. Fukuda, H. Fujinaga, K. Matsumoto, A. Matsuda, H. Saito

The effects of cetirizine and its enantiomers on the transport of monoamines by the human organic cation transporter OCT2 R. Whomsley, M. Strolin Benedetti, C. De Vos, T. Wunz, S. Wright, S. Narikawa, X. Yi

An intranasal steroid reduces eye symptoms after repetitive nasal challenges with allergen R.M. Naclerio, F.M. Baroody

Common traits and individualized patterns in the human IgE repertoire M. Mempel, A. Lim, B. Belloni, B. Lemercier, C. Andres, C. Schnopp, S. Weidinger, J. Ring, M. Ollert

Sublingual latex immunotherapy: safety and efficacy in an anaesthesiologist with latex professional exposure V. Patella, G. Florio, M. Milani

Old and new therapy for hereditary angioedema D.E. Sloane, A.L. Sheffer


261 267 271



283 287

291 293