international cancer research conference - Windsor Cancer Research

international cancer research conference - Windsor Cancer Research

Windsor Cancer Research Group 2ndBiennial INTERNATIONAL CANCER RESEARCH CONFERENCE NOVEMBER 22, 2014 Caesars Windsor Convention Centre Windsor – Ont...

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Windsor Cancer Research Group 2ndBiennial

INTERNATIONAL CANCER RESEARCH CONFERENCE

NOVEMBER 22, 2014 Caesars Windsor Convention Centre Windsor – Ontario – Canada

www.windsorcancerresearch.ca

CONFERENCE OVERVIEW 8:00 am

Registration, light breakfast and poster set up

LOBBY & AUGUSTUS II

8:45 am

Welcome

AUGUSTUS II

9:00 am

Opening Keynote Address:

AUGUSTUS II

HAS ANYONE EVER ACTUALLY BEEN HARMED BECAUSE OF A BREACH OF PROPERLY DE-IDENTIFIED HEALTH RESEARCH DATA? Dr. Craig Earle, Ontario Institute for Cancer Research (OICR)

10:00 am – 12 pm

Joint Session Moderators: Caroline Hamm, WCRG, Windsor Regional Cancer Centre and Dora Cavallo-Medved, WCRG, University of Windsor

AUGUSTUS II

12:15 pm

Lunch

AUGUSTUS II

1:30 – 3:30 pm

Concurrent Break Out Session A Moderators: Swati Kulkarni, WCRG, Windsor Regional Cancer Centre and Glenn Bauman, London Regional Cancer Program at Victoria Hospital and Schulich School of Medicine and Dentistry at Western University

MERCURI

1:30 – 3:30 pm

Concurrent Break Out Session B Moderators: Otis Vacratsis, WCRG, University of Windsor and Gabriel DiMattia, London Regional Cancer Centre

MARTIS

4:00 – 5:55 pm

Poster session

AUGUSTUS I

6:00 pm

Banquet featuring Keynote Address:

AUGUSTUS II

THE FALLOPIAN TUBE AS A PLATFORM FOR UNDERSTANDING OVARIAN CANCER PATHOGENESIS AND DRIVING DRUG DISCOVERY Dr. Ron Drapkin, Dana-Farber Cancer Institute

www.windsorcancerresearch.ca

KEYNOTE SPEAKERS

Dr. Craig Earle, MD, M.Sc. Program Director, Health Services Research, Ontario Institute for Cancer Research (OICR)

Dr. Craig Earle is a medical oncologist specializing in gastrointestinal cancers at Sunnybrook’s Odette Cancer Centre, a Professor of Medicine at the University of Toronto and a Senior Scientist at the Institute for Clinical Evaluative Sciences. Dr. Earle received his B.Sc. in Biochemistry in 1989, his M.D. in 1990, and his M.Sc. in Epidemiology in 1998 from the University of Ottawa. In 1998, he moved to Boston where he was an Associate Professor of Medicine at Harvard Medical School and Associate Professor of Health Policy and Management at the Harvard School of Public Health. While there, he was the founding Director of the Lance Armstrong Foundation Adult Survivorship Clinic at Dana-Farber Cancer Institute. Dr. Earle returned to Ontario in 2008 to be the Director of Health Services Research for Cancer Care Ontario and the Ontario Institute for Cancer Research, a joint effort to enhance Ontario’s capacity to study how the organization and delivery of its cancer services affects the quality and outcomes of care. He also currently serves as Chair of the Ontario Steering Committee for Cancer Drug Programs. His personal research interests focus on evaluating and improving the quality of care received by patients with advanced cancer and cancer survivors, the effect of financial incentives on care delivery, and making linked de-identified administrative data more available for health research.

Dr. Ronny Drapkin, MD, Ph.D. Principal Investigator, Medical Oncology, Dana-Farber Cancer Institute

Dr. Ronny Drapkin is an Associate Professor at Harvard Medical School, an Associate Pathologist at Brigham and Women’s Hospital and a Principle Investigator at the Dana-Farber Cancer Institute. Dr. Drapkin received his B.A. in Biochemistry from Brandeis University in 1990 and his M.D. and Ph.D. from the Rutgers Health Sciences - Robert Wood Johnson Medical School in 1998. He completed his residency in Anatomic Pathology at Brigham and Women’s Hospital in 2001 and a postdoctoral fellowship at the Dana-Farber Cancer Institute in 2006. He joined the faculty at Harvard in 2006. Dr. Drapkin serves on the editorial boards of Clinical Cancer Research and Gynecologic Oncology and his laboratory is funded by NIH/NCI grants, foundations and philanthropic gifts. Research in the Drapkin laboratory focuses on developing a comprehensive understanding of cancer pathogenesis, DNA repair mechanisms, and genomics of women’s cancers with a special focus on ovarian carcinomas. The ultimate goal is to translate important principles discovered in the laboratory into clinical useful diagnostic and therapeutic tools.

CONFERENCE PROGRAM SCHEDULE 8:00 am

Registration, light breakfast and poster set up

LOBBY & AUGUSTUS II

8:45 am

Welcome

AUGUSTUS II

9:00 am

Opening Keynote Address: HAS ANYONE EVER ACTUALLY BEEN

AUGUSTUS II

HARMED BECAUSE OF A BREACH OF PROPERLY DE-IDENTIFIED HEALTH RESEARCH DATA? Dr. Craig Earle, Ontario Institute for Cancer Research (OICR)

10:00 am – 12:00 pm

Joint Session

AUGUSTUS II

Moderators: Caroline Hamm, WCRG, Windsor Regional Cancer Centre and Dora Cavallo-Medved, WCRG, University of Windsor ABSTRACT O1 KISS1R SIGNALLING IN TRIPLE NEGATIVE BREAST CANCER Moshmi Bhattacharya Presenter Affliation: Western University, Department of Physiology and Pharmacology, Oncology ABSTRACT O2 “IT IS NOT EASY, THEREFORE A LOT OF PEOPLE THEY DO NOT WANT TO GO”: EXAMINING THE CANCER SCREENING PRACTICES FOR MUSLIM WOMEN Jamie Crawley Presenter Affliation: University of Windsor, Faculty of Nursing, ABSTRACT O3 PERSONALIZED CANCER THERAPY: ARMED SERIAL KILLER T CELLS AS CANCER VACCINES Lawrence Lum Presenter Affliation: Wayne State University and Karmanos Cancer Institute ABSTRACT O4 TUMOR ASSOCIATED MONOCYTES AUGMENT INVASION OF INFLAMMATORY BREAST CANCER CELLS VIA PROTEOLYTIC ACTIVITY AND EPITHELIAL MESENCHYMAL TRANSITIONDEPENDENT MECHANISMS Mona Mostafa Mohamed Presenter Affiliation: Faculty of Science, Cairo University, Giza, Egypt www.windsorcancerresearch.ca

ABSTRACT O5 COMPLEXITY OF NATURAL HEALTH PRODUCTS: GOOD OR BAD? ANTICANCER ACTIVITY OF LONG PEPPER EXTRACT (POLYCHEMICAL MIXTURE) VERSUS PURE PIPERLONGUMINE Siyaram Pandey Presenter Affiliation: Department of Chemistry and Biochemistry, University of Windsor 12:15 pm

Lunch

AUGUSTUS II

1:30 – 3:30 pm

Concurrent Break Out Session A

MERCURI

Moderators: Swati Kulkarni, WCRG, Windsor Regional Cancer Centre and Glenn Bauman, London Regional Cancer Program at Victoria Hospital and Schulich School of Medicine and Dentistry at Western University ABSTRACT O6 OUTCOMES OF PATIENTS WITH TRIPLE NEGATIVE BREAST CANCER COMPARED TO NON-TRIPLE NEGATIVE BREAST CANCER. A SINGLE CENTRE STUDY Caroline Hamm Presenter Affiliation: Schulich School of Medicine, University of Windsor and Windsor Cancer Research Group ABSTRACT O7 USE AND IMPACT OF INTERMITTENT VERSUS CONTINUOUS SYSTEMIC TREATMENT STRATEGIES IN METASTATIC COLORECTAL CANCER IN ROUTINE PRACTICE Amin Kay Presenter Affiliation: Windsor Regional Cancer Centre and University of Toronto ABSTRACT O8 FIRST NATIONS AND MÉTIS PEOPLES’ PERSPECTIVES AND EXPERIENCES CONCERNING CANCER SCREENING IN SOUTHWESTERN ONTARIO Heather Krohn Presenter Affiliation: Faculty of Nursing, University of Windsor

www.windsorcancerresearch.ca

ABSTRACT O9 INTENSITY MODULATED RADIOTHERAPY IMPROVED HEAD AND NECK CANCER OUTCOME IN WINDSOR ONTARIO Ming Pan Presenter Affiliation: Windsor Regional Hospital Cancer Program ABSTRACT O10 TREATMENT OUTCOMES OF PATIENTS DURING THE FIRST 10 YEARS OF THE WINDSOR REGIONAL CANCER CENTRE HIGH-DOSE-RATE (HDR) PROSTATE BRACHYTHERAPY PROGRAM Colvin Springer Presenter Affiliation: Windsor Regional Hospital ABSTRACT O11 CT-PERFUSION MEASUREMENTS AS A PREDICTOR OF PATIENT OUTCOME FOR TRANSARTERIAL CHEMOEMBOLIZATION (TACE) OF LIVER TUMORS Mark Dekaban Presenter Affiliation: Department of Medical Biophysics, University of Western Ontario; Imaging Research Labs, Robarts Research Institute 1:30 – 3:30 pm

Concurrent Break Out Session B

MARTIS

Moderators: Otis Vacratsis, WCRG, University of Windsor and Gabriel DiMattia, London Regional Cancer Centre ABSTRACT O12 SOLID LIPID NANOPARTICLES AS CHEMO PREVENTIVE TOPICAL DELIVERY SYSTEM IN SKIN CANCER MICE MODEL. Tranum Kaur Presenter Affiliation: Department of Chemistry and Biochemistry, University of Windsor ABSTRACT O13 STUDYING TUMOUR METABOLISM; USING HYPERPOLARIZED 13C PYRUVATE MAGNETIC RESONANCE IMAGING. Heeseung Lim Presenter Affiliation: Medical Biophysics, Western University

www.windsorcancerresearch.ca

ORAL PRESENTATIONS JOINT SESSION – AUGUSTUS II ABSTRACT O1 KISS1R SIGNALLING IN TRIPLE NEGATIVE BREAST CANCER Moshmi Bhattacharya* Presenter Affliation: Western University, Department of Physiology and Pharmacology, Oncology ABSTRACT O2 “IT IS NOT EASY, THEREFORE A LOT OF PEOPLE THEY DO NOT WANT TO GO”: EXAMINING THE CANCER SCREENING PRACTICES FOR MUSLIM WOMEN Jamie Crawley*, Israa El-Masri, Maher El-Masri Presenter Affliation: University of Windsor, Faculty of Nursing, ABSTRACT O3 PERSONALIZED CANCER THERAPY: ARMED SERIAL KILLER T CELLS AS CANCER VACCINES Lawrence Lum* Presenter Affliation: Wayne State University and Karmanos Cancer Institute ABSTRACT O4 TUMOR ASSOCIATED MONOCYTES AUGMENT INVASION OF INFLAMMATORY BREAST CANCER CELLS VIA PROTEOLYTIC ACTIVITY AND EPITHELIAL MESENCHYMAL TRANSITION-DEPENDENT MECHANISMS Mona Mostafa Mohamed*, Eslam A. El-Ghonaimy, M. Akram Nouh, Robert J. Schneider, Dora Cavallo-Medved, Bonnie F. Sloane, Mohamed El-Shinawi Presenter Affiliation: Faculty of Science, Cairo University, Giza, Egypt ABSTRACT O5 COMPLEXITY OF NATURAL HEALTH PRODUCTS: GOOD OR BAD? ANTICANCER ACTIVITY OF LONG PEPPER EXTRACT (POLYCHEMICAL MIXTURE) VERSUS PURE PIPERLONGUMINE Siyaram Pandey*, Pamela Ovadje, Dennis Ma, Philip Tremblay, Ammar Saleem, Jose-Antonio Guerrerro, John Thor Arnason Presenter Affiliation: Department of Chemistry and Biochemistry, University of Windsor

*Presenting Author

CONCURRENT BREAK OUT SESSION A – MERCURI MEETING ROOM ABSTRACT O6 OUTCOMES OF PATIENTS WITH TRIPLE NEGATIVE BREAST CANCER COMPARED TO NON-TRIPLE NEGATIVE BREAST CANCER. A SINGLE CENTRE STUDY Caroline Hamm*, Maher El-Masri, S. Kulkarni, R. Gupta, Y. Alam, J. Mathews, A. Ghafoor, T. Elfiki, S. Kanjeekal, M. Pan, K. Schneider, J. Yousuf, C. Springer, K. Hirmiz Presenter Affiliation: Schulich School of Medicine, University of Windsor and Windsor Cancer Research Group ABSTRACT O7 USE AND IMPACT OF INTERMITTENT VERSUS CONTINUOUS SYSTEMIC TREATMENT STRATEGIES IN METASTATIC COLORECTAL CANCER IN ROUTINE PRACTICE Amin Kay*, Lingsong Yun, Nathan Taback, Monika K. Krzyzanowska Presenter Affiliation: Windsor Regional Cancer Centre and University of Toronto ABSTRACT O8 FIRST NATIONS AND MÉTIS PEOPLES’ PERSPECTIVES AND EXPERIENCES CONCERNING CANCER SCREENING IN SOUTHWESTERN ONTARIO Heather Krohn*, Maher El-Masri, Neelu Sehgal, Audrey Logan, Presenter Affiliation: Faculty of Nursing, University of Windsor ABSTRACT O9 INTENSITY MODULATED RADIOTHERAPY IMPROVED HEAD AND NECK CANCER OUTCOME IN WINDSOR ONTARIO Ming Pan*, Ken Schneider, Swati Kulkarni, Daphne Southcott, Yasmin Alam, Pamathy Vivek, Rasna Gupta, Akmal Ghafoor, John Mathews, Tarek A. Elfiki, Sindu Mary Kanjeekal, Khalid Hirmiz, Junaid Yousuf, Colvin Springer, Caroline M. Hamm Presenter Affiliation: Windsor Regional Hospital Cancer Program ABSTRACT O10 TREATMENT OUTCOMES OF PATIENTS DURING THE FIRST 10 YEARS OF THE WINDSOR REGIONAL CANCER CENTRE HIGH-DOSE-RATE (HDR) PROSTATE BRACHYTHERAPY PROGRAM Colvin Springer*, Junaid Yousuf, Khalid Hirmiz, Ming Pan, Ron Sorensen, Siobhan Ozard, Elizabeth Skeates, Jennifer Stone Presenter Affiliation: Windsor Regional Hospital ABSTRACT O11 CT-PERFUSION MEASUREMENTS AS A PREDICTOR OF PATIENT OUTCOME FOR TRANSARTERIAL CHEMOEMBOLIZATION (TACE) OF LIVER TUMORS Mark Dekaban*, Errol Stewart, Nirmal Kakani, Amol Mujoomdar, Yong Wang, Ting-Yim Lee, Aaron Fenster Presenter Affiliation: Department of Medical Biophysics; University of Western Ontario; Imaging Research Labs, Robarts Research Institute

*Presenting Author

CONCURRENT BREAK OUT SESSION B – MARTIS MEETING ROOM ABSTRACT O12 SOLID LIPID NANOPARTICLES AS CHEMO PREVENTIVE TOPICAL DELIVERY SYSTEM IN SKIN CANCER MICE MODEL. Tranum Kaur*, Indu Pal Kaur, Sankar Sanyal, Kim Vaiphei, Vandita Kakkar, Rishi Bhardwaj, Kavita Mittal Presenter Affiliation: Department of Chemistry and Bio-chemistry, University of Windsor, ABSTRACT O13 STUDYING TUMOUR METABOLISM; USING HYPERPOLARIZED 13C PYRUVATE MAGNETIC RESONANCE IMAGING. Heeseung Lim*, Kundan Thind, Timothy Pok Chi Yeung Presenter Affiliation: Medical Biophysics, Western University, London, Ontario, Canada ABSTRACT O14 TAFIA IS A NOVEL INHIBITOR OF TUMOUR ANGIOGENESIS IN BREAST CANCER Jennifer Balun*, Lisa A. Porter, Dora Cavallo-Medved, Michael B Boffa Presenter Affiliation: Department of Chemistry and Biochemistry, University of Windsor ABSTRACT O15 NOVEL CELL CYCLE IN MAMMARY GLAND DEVELOPMENT: IMPLICATIONS OF SPY1 IN MAMMARY TUMOUR SUSCEPTIBILITY Bre-Anne Fifield*, RD Cardiff, LA Porter Presenter Affiliation: Department of Biological Sciences, University of Windsor ABSTRACT O16 TOWARDS A MODEL FOR THE POLO-LIKE KINASES AND EPIGENETIC REGULATION Alejandra Ward*, Gayathri Sivakumar, John Hudson Presenter Affiliation: Department of Biological Sciences, University of Windsor

*Presenting Author

POSTER PRESENTATIONS – AUGUSTUS I ABSTRACT P01 TUBERIN EXPRESSION AND FUNCTION IN MAMMALIAN BRAIN DEVELOPMENT Bashaer Abu Khatir* Presenter affiliation: University of Windsor ABSTRACT P02 EVALUATION OF ANTI-CANCER ACTIVITY OF SYNTHETIC ANALOGUES OF CURCUMIN ALONE & IN COMBINATION WITH PIPERLONGUMINE Scott Adams*, Kristen Larocque, Dennis Ma,Tyler Gilbert, Chris Pignanelli, Melissa Cowell, Fatmeh Hourani, Jesse Ropat, Megan Noel, Rabia Hadi, Yi Wang, Guang Liang, Siyaram Pandey Presenter affiliation: University of Windsor ABSTRACT P03 QUANTITATIVE EVALUATION OF VASCULAR RESPONSE FOLLOWING FOCUSED ULTRASOUND AND MICROBUBBLE TREATMENT IN THE CONTEXT OF IMPROVING DRUG DELIVERY Hassaan Ahmed,* Rajiv Chopra, Kullervo Hynynen, Ting Lee Presenter affiliation: Western University ABSTRACT P04 TARGETED-ALBUMIN IMAGING IN SOLID TUMOURS USING DELTA RELAXATION-ENHANCED MAGNETIC RESONANCE IMAGING (DREMR) Yonathan Araya*, Francisco Martinez-Santiesteban, Chad Harris, William Handler, Paula Foster, Blaine Chronik, Timothy Scholl Presenter affiliation: Western University ABSTRACT P05 COLONIC TUMORS EXPRESS LOW LEVEL OF LDL RECEPTOR PROTEIN : AN INVESTIGATION INTO THE UNDERLYING MECHANISM Vaishali Basu* John Hudson, Ranjana Bird Presenter affiliation: University of Windsor ABSTRACT P06 ROLE OF KISS1R IN BREAST CANCER CHEMORESISTANCE Alexandra Blake,* Magdalena Dragan, Rommel Tirona, Moshmi Bhattacharya Presenter affiliation: University of Western Ontario

*Presenting Author

ABSTRACT P07 COMPARISON OF SURVIVAL IN PANCREATIC DUCTAL ADENOCARCINOMA PATIENTS TREATED WITH ADJUVANT OR CHEMOTHERAPY VERSUS SURGICAL RESECTION OR SUPPORTIVE THERAPY RESPECTIVELY Michael Blaszak*, Maher El-Masri, Khalid Hirmiz, John Mathews, Abeer Omar, Akmal Ghafoor Presenter affiliation: Schulich School of Medicine & Dentistry, Western University ABSTRACT P 08 UTILIZATION OF A NOVEL G2 REPORTER SYSTEM IN THE STUDY OF THE TUBERIN-CYCLIN B1 INTERACTION Sabrina Botsford*, Elizabeth Fidalgo da Silva, Lisa A. Porter Presenter affiliation: Schulich School of Medicine and Dentistry - University of Windsor Campus ABSTRACT P09 FASCAPLYSIN ACTS BY MULTIPLE MECHANISMS INCLUDING DNA INTERCALATION Nicholas Carruthers*, Paul Stemmer, Frederick Valeriote Presenter affiliation: Wayne State University ABSTRACT P10 IDENTIFICATION OF ALTERNATIVE RNA SPLICING AS A KEY REGULATOR OF CANCER EVOLUTION USING A PHOSPHOPROTEOMIC –BASED SYSTEMS APPROACH. Joseph Caruso*, Paul Stemmer, Alan Dombkowski Presenter affiliation: Wayne State University ABSTRACT P11 ROLE OF CAVEOLIN-1 IN THE PROSTATE TUMOUR MICROENVIRONMENT Dora Cavallo-Medved*, Lisa Porter, Deborah Rudy Presenter affiliation: University of Windsor ABSTRACT P12 PLK4 HETEROZYGOSITY AND THE DEREGULATION OF DNMT3A Andrei Cerghet*, Alejandra Ward, Sharon Yong, John Hudson Presenter affiliation: University of Windsor ABSTRACT P13 THE ACETYLENIC TRICYCLIC BIS-(CYANO ENONE) INTERACTS WITH CYSTEINE RESIDUES ON ACTIN TO INHIBIT NON-SMALL CELL LUNG CANCER CELL MIGRATION Eddie Chan*, Akira Saito, Peter C. Cavanaugh, Jimmy Dikeakos, Tadashi Honda, Gianni M. Di Guglielmo, Presenter affiliation: University of Western Ontario ABSTRACT P14 MONITORING THE MITOTIC TRANSITION THROUGH TIME LAPSE FLUORESCENCE Jessica Dare*; Marisa Market*, Sabrina Botsford, Elizabeth Fidalgo Da Silva, Lisa A. Porter Presenter affiliation: University of Windsor *Presenting Author

ABSTRACT P15 THE ROLE OF AMINO ACIDS IN INITIATING INSULIN RESISTANCE WITHIN SKELETAL MUSCLE Preet Dhillon*, Kanwar Dhaliwal Presenter affiliation: Schulich School of Medicine and Dentistry/ York University ABSTRACT P16 THE PRIMARY CLERK MODEL: EMBEDDING A CLERK IN THE HEALTH CARE TEAM Jen Difazio*, Caroline Hamm, Suzanne Purves, Claudia den Boers Presenter affiliation: Windsor Regional Cancer Program ABSTRACT P17 THE ROLE OF SPY1 IN BREAST CANCER TREATMENT RESISTANCE Rosa-Maria Ferraiuolo*, Janice Tubman, Indrajit Sinha, Caroline Hamm, Lisa A. Porter Presenter affiliation: University of Windsor ABSTRACT P18 INTERACTIONS BETWEEN TUBERIN AND CYCLIN B1 FUNCTION AS A G2/M GROWTH FACTOR SENSOR Elizabeth Fidalgo da Silva*, Kaitlin Martinello, Miranda Hanna, Lisa Porter Presenter affiliation: University of Windsor ABSTRACT P19 BREAST CANCER SUBTYPES IDENTIFICATION USING A HIERARCHICAL CLASSIFICATION MODEL Forough Firoozbakht*, Iman Rezaeian, Alioune Ngom, Lisa Porter, Luis Rueda Presenter affiliation: University of Windsor, School of Computer Science ABSTRACT P20 A RETROSPECTIVE COMPARISON OF HIGH DOSE RATE BRACHYTHERAPY AND EXTERNAL BEAM RADIOTHERAPY IN THE TREATMENT OF HIGH RISK CLINICALLY LOCALIZED PROSTATE CANCER Dan Gillett*, Umair Majid*, Junaid Yousuf, Abeer Omar, Colvin Springer, Khalid Hirmiz, Ming Pan, Sindu Kanjeekal, John Matthews, Yasmin Alam, Tarek Elfiki, Akmal Ghafoor, Rasna Gupta, Caroline Hamm, Swati Kulkarni, Ken Schneider Presenter affiliation: Windsor Regional Hospital ABSTRACT P21 GADD45A, A SUBSTRATE OF POLO-LIKE KINASE 4, IMPLICATES THE PROTEIN KINASE WITH A NOVEL ROLE IN THE DNA DAMAGE SIGNALING NETWORK Natalie Gosselin*, Gayathri Sivakumar, Alejandra Ward, Bing Wu, Anna Kozarova, John W. Hudson Presenter affiliation: University of Windsor ABSTRACT P22 ASSESSING BRAIN METASTASES DUE TO BREAST CANCER AND MELANOMA USING CELLULAR MAGNETIC RESONANCE IMAGING Mariama Henry*, Carmen Simedrea, Catherine McFadden, Yuhua Chen, Paula J. Foster Presenter affiliation: Western University/ University of Windsor *Presenting Author

ABSTRACT P23 HEMATOLOGICAL TOXICITIES IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA ON COMBINED RADIATION AND TEMOZOLAMIDE- SINGLE INSTITUTION EXPERIENCE Swati Kulkarni*, Z. Alam, K. Schneider, K. Hirmiz Presenter affiliation: Windsor Regional Cancer Program, Windsor / Medical Oncologist ABSTRACT P24 DEXAMETHASONE VARIABLY PROTECTS TRIPLE NEGATIVE BREAST CANCER CELLS AGAINST PACLITAXEL DEPENDING ON RELATIVE CELLULAR LEVELS OF GLUCOCORTICOID RECEPTOR ALPHA Roselyne Labbe*, Rafa Khansa, Austin Belfiori, Miriam Bukhsh, Mugdha Patki, Manohar Ratnam, David Gorski, Cecilia Speyer Presenter affiliation: Wayne State University School of Medicine ABSTRACT P25 HIGH INCIDENCE OF SPLENOMEGALY AND SPLEEN TUMOURS IN PLK4 HETEROZYGOUS MICE: A POTENTIAL MONOCLONAL GAMMOPATHY MOUSE MODEL Brayden LaBute*, Alejandra Ward, Deanna Owen, John Hudson* Presenter affiliation: University of Windsor ABSTRACT P26 A REVIEW OF EMERGENCY DEPARTMENT (ED) VISITS BY WRCC HAEMATOLOGY PATIENTS Christopher Langley*, Caroline Hamm Presenter affiliation: Schulich School of Medicine & Dentistry, Western University ABSTRACT P27 FUNCTIONAL CFTR SUPPRESSES LUNG CANCER TUMORIGENESIS AND PROGRESSION VIA MODULATING EGFR SIGNALING Chunying Li*, Yuning Hou , Guan, Xiaoqing, Zhe Yang, Fei Sun, Chunying Li Presenter affiliation: Wayne State University ABSTRACT P28 EXPLOITING MITOCHONDRIAL VULNERABILITIES WITH PANCRATISTATIN & PANCRATISTATIN ANALOGUES IN COMBINATION WITH CURCUMIN, TAMOXIFEN, & PIPERLONGUMINE FOR CANCER THERAPY Dennis Ma*, Daniel Tarade , Scott Adams , Tyler Gilbert , Chris Pignanelli, Melissa Cowell, Sergey Vshyvenko, Tomas Hudlicky, James McNulty, Siyaram Pandey Presenter affiliation: University of Windsor ABSTRACT P29 CATALYTIC RING CLOSING METHODS FOR THE SYNTHESIS OF ALLOCOLCHICINES (A CLASS OF ANTICANCEROUS COMPOUNDS) Mariam Mehdi*, James R. Green, Sinisa Djurdjevic Presenter affiliation: University of Windsor

*Presenting Author

ABSTRACT P30 A RETROSPECTIVE REVIEW OF THE PERCENTAGE OF PRE-SCREENED PATIENTS WHO WERE ENROLLED ONTO A CLINICAL TRIAL AT THE WINDSOR REGIONAL HOSPITAL CANCER PROGRAM Krista Naccarato* Presenter affiliation: Windsor Regional Hospital Cancer Program ABSTRACT P31 WHY DO BREAST CANCER PATIENTS VISIT THE EMERGENCY DEPARTMENT? Abdullah Nasser*, Swati Kulkarni Presenter affiliation: Schulich School of Medicine and Dentistry ABSTRACT P32 THE ROLE OF FIBULIN-3 IN BREAST CANCER Michelle Noonan*, Dragan Magdalena, Bhattacharya Moshmi, Presenter affiliation: The University of Western Ontario ABSTRACT P33 PRECLINICAL EVALUATION OF THE ANTICANCER EFFICACY OF AQUEOUS DANDELION ROOT EXTRACT IN HUMAN COLORECTAL CANCER CELLS Pamela Ovadje*, Caroline Hamm, Ammar Saleem, John Thor Arnason, Siyaram Pandey, Presenter affiliation: University of Windsor ABSTRACT P34 IN VIVO SODIUM MRI OF HUMAN PROSTATE CANCER Justin Peterson*, Adam Farag, Trevor Szekeres, Eli Gibson, Aaron Ward, Joseph Chin, Stephen Pautler, Glenn Bauman, Cesare Romagnoli, Robert Bartha, Timothy J. Scholl, Presenter affiliation: Medical Biophysics, Western University, London, Ontario ABSTRACT P35 PRE-CLINICAL SCREENING AND EVALUATION OF VARIOUS NATURAL HEALTH PRODUCTS FOR THEIR ANTI-CARCINOGENIC PROPERTIES Cory Philion*, Grace Tesky, Pamela Ovadje and Siyaram Pandey Presenter affiliation: University of Windsor ABSTRACT P36 ROLE OF SPY1 IN NEUROGENESIS; IMPLICATIONS IN DEVELOPMENT OF HIGH GRADE GLIOMA Ingrid Qemo*, Dorota Lubanska, Bre-Anne Fifield and Lisa A. Porter Presenter affiliation: University of Windsor, Department of Biological Sciences ABSTRACT P37 ANALYSIS OF A HYBRID PLASMONIC WAVEGUIDE BIOSENSOR IN TURBID MEDIA Chitra Rangan*, Daniel Travo, John Sipe Presenter Affiliation: Department of Physics, University of Windsor

*Presenting Author

ABSTRACT P38 NEEM LEAF EXTRACTS AND APOPTOTIC INDUCTION: A POTENTIAL ANTI-CANCER THERAPY Alessia Roma*, Matthew Steckle, Leah Nicoletti, Pamela Ovadje, Siyaram Pandey Presenter affiliation: University of Windsor ABSTRACT P39 FINDING DIFFERENTIAL SPLICE JUNCTIONS AS BIOMARKERS IN PROSTATE CANCER FROM NEXT GENERATION SEQUENCING DATA Luis Rueda*, Iman Rezaeian, Ahmad Tavakoli, Dora Cavallo-Medved, Lisa Porter Presenter affiliation: University of Windsor ABSTRACT P40 FIRST LINE TYROSINE KINASE INHIBITORS THERAPY IN CHRONIC MYELOID LEUKEMIA AT THE CANCER PROGRAM OF WINDSOR REGIONAL HOSPITAL (2001-2013) Daad Sayegh*, D. Sayegh, S. Kanjeekal, J. Mathews, R. Gupta, T. Elfiki, Y. Alam, A. Ghafoor, S. Kulkarni, K. Schneider, J. Yousuf, K. Hirmiz, C. Springer, M. Pan, C. Hamm Presenter affiliation: Naom Medicine Professioal Corporation ABSTRACT P41 ETHANOLIC EXTRACT OF LONG PEPPER TARGETS CANCER CELL MITOCHONDRIA FOR THE INDUCTION OF APOPTOSIS Michael Stanesic*, Pamela Ovadje, Dennis Ma, Ammar Saleem, John Thor Arnason, Siyaram Pandey, Presenter affiliation: University of Windsor ABSTRACT P42 NATURAL EXTRACTS OF TULSI AS ANTIOXIDANTS AND INDUCERS OF APOPTOSIS IN CANCER Matthew Steckle*, Leah Nicoletti, Pamela Ovadje, Siyaram Pandey, Presenter affiliation: University of Windsor ABSTRACT P43 HEPATIC ARTERIAL BLOOD FLOW PRIOR TO THERAPY PREDICTS TREATMENT RESPONSE FROM ANGIOGENESIS INHIBITORS IN AN ANIMAL MODEL OF HCC Errol Stewart*, Anita Gandhi, Peter Schafer, Ting-Yim Lee Presenter affiliation: Imaging Laboratory Robarts Research the University of Western Ontario ABSTRACT P44 EFFECT OF NOVEL BIARLY ANALOGS OF COMBRETASTATIN A4 ON CELL CYCLE PROGRESSION & MITOCHONDRIAL STABILITY IN CANCEROUS CELLS Daniel Tarade*, Dennis Ma, Seema Joshi, Julia Church, Sean van den Berg, James McNulty Presenter affiliation: University of Windsor

*Presenting Author

ABSTRACT P45 A ROLE FOR SPY1 IN BREAST CANCER METASTASIS Janice Tubman*, Indra Sinha, Lisa A. Porter Presenter affiliation: University of Windsor ABSTRACT P46 MYBC CANCER APP: A MOBILE APPROACH TO DELIVERING LOCAL CANCER RESOURCES AND FACILITATING PATIENT TREATMENT PLANS IN BRITISH COLUMBIA. Wesley Wilson*, Bree Galbraith, Carr Emily Presenter affiliation: University of British Columbia ABSTRACT P47 TOXICITIES RELATED TO DOSE DENSE AC-TAXOL IN EARLY BREAST CANCER: LRCP AND WRCC EXPERIENCE Michael Yan*, Jawaid Younus, E Tashkandi Presenter affiliation: Western University

*Presenting Author

Thank You to Our Conference Organizers and Volunteers Thank you to the WCRG Conference Organizing Committee and our group of dedicated student volunteers for contributing their time, ideas and enthusiasm to this conference. Their commitment and efforts made all of this possible.

WCRG CONFERENCE ORGANIZING COMMITTEE Michael Boffa Dora Cavallo-Medved Caroline Hamm Marlys Koschinsky Swati Kulkarni

Marisa Market Karen Metcalfe Lisa Porter Andrew Swan Otis Vacratsis

STUDENT VOLUNTEERS Mitchell Elliott, Volunteer Team Leader Marisa Market, Volunteer Team Leader

Dena Ali Tashea Albano Raghd Al-Olabi Rachel Andrews Maria Boxwala Mubaraka Boxwala Eve Deck Lana El Osta Melanie Grondin

Shelby Koschuck Jesse Market Joe Najem William Roeder Ahmed Salim Charbel Tannous Samia Toor Chantelle Trombley Mubarak Ziab

www.windsorcancerresearch.ca

We would like to take this opportunity to thank all of the participants of the

Windsor Cancer Research Group 2nd Biennial International Cancer Research Conference

To learn more about the Windsor Cancer Research Group please go to our website at www.windsorcancerresearch.ca or

www.facebook.com/Windsorcancerresearchgroup

www.bearconstruction.ca

GRAND CHALLENGES AND ASPIRATIONS The University of Windsor has recast its strategic research priorities into four Grand Challenges: Healthy Great Lakes; Viable, Healthy and Safe Communities; Sustainable Industry; and Understanding Borders. These Grand Challenges are based on our geographical location and our historic research strengths. They collectively define us and tell the external world our aspirations and goals. No other Canadian university can tackle these challenges simultaneously today.

UWINDSOR

RESEARCH Contact Us Office of the Vice-President, Research and Innovation University of Windsor 401 Sunset Avenue, Windsor, Ontario, Canada N9B 3P4 Tel: (519) 253-3000 x 3925 Fax: (519) 971-3667 Email: [email protected]

www.uwindsor.ca/research

Fighting

Serious Diseases At Bristol-Myers Squibb, our commitment to develop innovative medicines is as strong as the patient’s will to fight serious diseases. Our researchers are working every day to discover the next generation of treatments in areas such as: • Cardiovascular • Fibrotic Diseases • Genetically Defined Diseases • Immuno-Oncology • Immunoscience • Oncology • Virology

To learn more about our commitment to patients around the world, visit www.bms.com © 2014 Bristol-Myers Squibb Company.

Genomic Health Genomic Health is the world’s leading provider of genomic-based diagnostic tests that address the overtreatment of early stage cancer, one of the greatest issues in healthcare today. Our goal is to improve the lives of people with cancer by developing clinically-actionable tests that personalize their treatment. Our Oncotype DX tests help early stage breast, colon and prostate cancer patients avoid the side effects and costs of treatments they don’t need, while directing therapy to those patients who will benefit from treatment. In this way, our work is truly life, changing. 

  

By analyzing the genes in a patient’s individual tumor, our tests provide information not available from any other test or procedure. This information helps patients and physicians choose the best treatment for each patient. Our Oncotype DX tests help to answer critical questions about the aggressiveness of a patient’s cancer, including the likelihood of disease recurrence and response to chemotherapy. We currently offer tests for breast, colon and prostate cancers to patients worldwide and hundreds of thousands of patients from over 70 countries have used an Oncotype DX test. Our first test, the Oncotype DX breast cancer test, will celebrate its tenth anniversary in 2014, and is considered standard of care in the US based on its inclusion in important national and international guidelines for breast cancer treatment.

At Genomic Health, we are united around our common purpose of improving the lives of people with cancer. We embrace our unique culture characterized by our Core Values of Community, Truth Seeking, Being Ahead of the Curve and Winning to be the best in the world at what we do.

The Faculty of Science is proud to continue to offer its support to our faculty, staff and research trainees who are engaged in activities in the area of cancer research. If you are interested in pursuing cancer research -related studies, please contact us at www.uwindsor.ca/science

CONFERENCE PARTICIPANTS Last name: Abu Khatir Adams Aljannati Araya Aslam Atikukke Balun Basu

First name: Bashaer Scott Salma Yonathan Seemab Govindaraja Jennifer Vaishali

Bauman

Glenn

Bazzi Belfiori Bhasin Bhattacharya Blake Blaszak Boffa

Zainab Austin Ashwini Moshmi Alexandra Michael Michael

Botsford

Sabrina

Carruthers Caruso Cavallo-Medved Cerghet Chan Chun Cowell Crawley

Nicholas Joseph Dora Andrei Eddie Helena Melissa Jamie

Institution/Affiliation: University of Windsor University of Windsor WCRG Western University University Of Windsor ITOS Oncology University of Windsor University of Windsor London Regional Cancer Program, Schulich School of Medicine and Dentistry at Western University University of Windsor Wayne State University School of Medicine Genomic Health Western University University of Western Ontario Schulich School of Medicine & Dentistry, Western University University of Windsor Schulich School of Medicine and Dentistry - University of Windsor Campus Wayne State University Wayne State University University of Windsor University of Windsor University of Western Ontario Eisai University of Windsor University of Windsor - Faculty of Nursing

E-mail address: [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected]

Last name: Dare-Shih Dekaban den Boer Grima Dhillon DiMattia Dragan Drapkin Dulmage Earle Elshani Ferraiuolo Fidalgo da Silva Fifield Firoozbakht Gilbert Gillett Gosselin Green Gupta Hadi Hamm Handrysiak Hayne Curtis Hebert Henry Hudson Igbokwe Karpowicz Kaur

First name: Jessica Mark Claudia Navpreet Gabriel Magdalena Ron Elizabeth Craig Bledi Rosa-Maria Elizabeth Bre-Anne Forough Tyer Dan Natalie James Rasna Rabia Caroline Sylwia Laura Catherine Mariama John Emmanuel Phillip Tranum

Institution/Affiliation: University of Windsor The University of Western Ontario Windsor Regional Hospital Schulich School of Medicine and Dentistry/ York University London Regional Cancer Centre The University of Western Ontario Dana-Farber Cancer Institute Windsor Regional Hospital, Cancer Program Ontario Institute for Cancer Research (OICR) University of Windsor University of Windsor University of Windsor University of Windsor school of computer science - University of Windsor University of Windsor Schulich School of Medicine and Dentistry University of Windsor University of Windsor Windsor Regional Hospital Cancer Program University of Windsor Schulich School of Medicine Windsor Regional Hospital Cancer Program Windsor Regional Cancer Centre Windsor Regional Hospital Cancer Program Western University/ University of Windsor University of Windsor University Of Windsor University of Windsor University of Windsor

E-mail address: [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected]

Last name: Kay Khansa Kim Kleinstiver Kogel Krohn Kulkarni Labbe LaBute Langley Lanoue Lee Li Lim

First name: Amin Rafa Jiwon Janice Sandra Emily Heather Swati Roselyne Brayden Christopher Danielle Sanghyun Chunying Heeseung

Logan

Audrey

Lum Luongo Ma Maimaiti Majid Marginean Market McClelland Mehdi Metcalfe Michaud Mostafa Mohamed Muthukumaran

Lawrence Laura Dennis Jiamila Umair Alexandra Marisa Richard Mariam Karen Bryher Mona Krithika

Institution/Affiliation: WRCC University of Michigan - Dearborn Windsor Regional Cancer Centre Western Centre for Translational Cancer Research - CTCR University of Windsor Faculty of Nursing, University of Windsor Windsor Regional Cancer Program Wayne State University School of Medicine University of Windsor Schulich School of Medicine & Dentistry, Western University University of Windsor Western University Wayne State University Robarts Research Institute, Western University Windsor Regional Hospital - Erie St. Clair Regional Cancer Program Wayne State University/Karmanos Cancer Institute Roche Pharma University of Windsor University of Windsor Windsor Regional Hospital University of Windsor University of Windsor L.R.C. Clinical Research Unit University of Windsor WCRG Bristol Myers Squibb Faculty of Science, Cairo University Giza, Egypt University of Windsor

E-mail address: [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected]

Last name: Naccarato Nangle Nasser Ngom Nicoletti Noel Noonan Ovadje Owen Pan Pandey Peterson Philion Pignanelli Porter Qemo Rangan Rendall Rezaeian Roma Ropat Rueda Sameem Sayegh Schneider Seehan Sobol Sohi Stanesic

First name: Krista Yvonne Abdullah Alioune Abbey Megan Michelle Pamela Deanna Ming Siyaram Justin Cory Chris Lisa Ingrid Chitra Chantal Iman Alessia Jesse Luis Mariam Daad Ken Ramu Joseph Jasloveleen Michael

Institution/Affiliation: Windsor Regional Hospital Cancer Program Novartis Pharma Schulich School of Medicine and Dentistry School of Computer Science, University of Windsor University of Windsor University of Windsor The University of Western Ontario University of Windsor University of Windsor Windsor Regional Hospital Cancer Program University of Windsor Western University University of Windsor University of Windsor University of Windsor/Windsor Cancer Research Group University of Windsor University of Windsor Roche Pharma University of Windsor University of Windsor University of Windsor University of Windsor University of Windsor Naom Medicine Professional Corporation Windsor Regional Hospital Cancer Program Astra Zeneca Windsor Regional Hospital Wayne State University University of Windsor

E-mail address: [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected]

Last name: Steckle Stones Stringer Swan Tarade Teskey Truant Tubman Vacratsis Ward Wasik Weeks- Schacter Wells

First name: Matthew Jennifer Keith Andrew Daniel Grace Ron Janice Otis Alejandra Zonia Carol Mari-Lynn

E-mail address: [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected]

Natasha Rebecca Jeanette

Institution/Affiliation: University of Windsor Windsor Regional Hospital University of Windsor University of Windsor University of Windsor University of Windsor WCRG University of Windsor University of Windsor University of Windsor Novartis Pharma Eisai Janssen Inc. Windsor Regional Hospital Cancer Program, Member of the Erie. St. Clair Regional Cancer Program Patient & Family Advisory Council University of Windsor/Research & Innovation Services University of Windsor Bristol Myers Squibb

White

Sarah

Wiebe Williams Wilson WoodworthGiroux Yan

Sarah Michael

Windsor Regional Cancer Center Western University

[email protected] [email protected]

[email protected] [email protected] [email protected] [email protected]

ACCREDITATION STATEMENT

This event is an Accredited Group Learning Activity (Section 1) as defined by the Maintenance of Certification program of The Royal College of Physicians and Surgeons of Canada and approved by Continuing Professional Development, Schulich School of Medicine & Dentistry, Western University (# hours) Each participant should claim only those hours of credit that he/she actually spent participating in the educational program.

www.windsorcancerresearch.ca

NOTES

www.windsorcancerresearch.ca

NOTES

www.windsorcancerresearch.ca

Thank You to Our Conference Sponsors This program was supported in part by an educational grant from the following

PLATINUM SPONSORS

GOLD SPONSORS

SILVER SPONSORS

BRONZE SPONSORS