Skid row cancer study has implications for treatment - Medical Xpress

Skid row cancer study has implications for treatment - Medical Xpress

Skid row cancer study has implications for treatment today, researcher says 18 October 2013 An ethically dubious medical research study from the 1950s...

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Skid row cancer study has implications for treatment today, researcher says 18 October 2013 An ethically dubious medical research study from the 1950s and 60s, known as the "Bowery series," foreshadowed and shared commonalities with prostate cancer screening and treatment measures as they are carried out today, argues University of Pennsylvania physician and historian Robert Aronowitz in two new publications.

study to determine whether biopsying the prostate glands of men without signs or symptoms, and then aggressively treating those individuals who had tissue diagnoses of cancer, could reduce deaths from prostate cancer.

Aronowitz details the history of the urologist's trial, which lasted more than a decade and to which more than 1,200 homeless, alcoholic men from In papers published in the American Journal of New York's Bowery neighborhood were recruited. Public Health and the Bulletin of the History of Medicine, Aronowitz, professor and chair of Penn's Participants traveled to Francis Delafield Hospital, where they received a physical exam, X-rays, and Department of History and Sociology of Science, various invasive tests, including a prostate biopsy characterizes the events then and screenings for that involved the removal of a sizable amount of prostate-specific antigen, or PSA, in more recent tissue. Men whose samples were found to contain years as "part of one continuous story of how cancerous cells then underwent aggressive medical and lay people came to believe in the treatment, typically including the removal of the efficacy of population screening followed by prostate gland and testes and administration of a aggressive treatment without solid supporting synthetic estrogen. scientific evidence." Though records are unclear, some men may have given a form of "informed consent" and some may have been aware that they were participating in research, Aronowitz found. But their vulnerable In 2012, the U.S. Preventive Services Task Force status, as homeless and alcoholic, calls into the question whether they were entering into the recommended that healthy men not be screened for prostate cancer with PSA tests. Millions of men, research with true free will and understanding, Aronowitz said. Given the state of clinical before and after this recommendation, have had screening PSA tests. If an individual's PSA level is knowledge, he noted, these largely asymptomatic above a certain value, he may be counseled by a men clearly were also being exposed to undue risk. doctor to have repeated tests or a tissue biopsy to Even though the prostate biopsy procedure today look for cancer cells. The biopsy is an invasive procedure, and can lead to additional procedures requires the removal of far less tissue and is less dangerous, Aronowitz draws a connection between that escalate in their potential for detrimental effects. The recent Task Force decision states that the vulnerable Bowery population and the millions of men who each year are biopsied for cancer after the test has "very small potential benefit and recording a high level on a PSA screening test. significant potential harms." "This is a call to reflection about how we deal with medical knowledge production and medical technological innovation," Aronowitz said.

Interested in how the PSA test and other prostate cancer screening measures rose in prominence, Aronowitz was researching the history of screening when he came upon a "largely forgotten" story. In 1951, a young New York urologist began a

"Patients today are often not fully informed about risks and benefits of PSA screening," Aronowitz said. "More importantly, and like the Bowery men, many men today, and certainly men in the era before results from good clinical trials were available, have not been informed in the sense of


knowing whether the test, and all that it may trigger, is worth it or not." In the Bulletin of the History of Medicine paper, Aronowitz writes that society's attitudes toward prostate cancer changed as a result of subsequent medical innovation that modified many aspects of the Bowery series but had similar goals. Where prostate cancer was once only diagnosed in very late stages when it was nearly always fatal, new screening tests enabled many diagnoses at much earlier stages, before patients displayed symptoms. According to Aronowitz, however, the evidence we now have from randomized controlled trials either does not show that screening saves lives or shows a very small benefit that many men will feel does not outweigh the many known harms from cancer treatments, especially incontinence and impotence. Whether efficacious or not, the mass diffusion of screening and related practices occurred in an "evidence-free" way and transformed prostate cancer as a disease, Aronowitz argued. "It's not just costly or a little bit inconvenient to let innovation happen and deal with the ethical and clinical consequences later," he said. "We ended up with not just 1,200 but millions of men who were screened, and maybe a fifth of them go on to get more radical treatment. "I think when you look back at the Bowery series, those involved were acting in good faith," he added. "So were many people who promoted PSA testing when they thought or continue to think it is only logical to use a test that detects cancer early enough for radical treatments to remove it from the body. But when a medical procedure will be offered at a population level with the potential to transform society and everything we think we know about the targeted disease, we ought to proceed with a very high level of caution, reflection, knowledge production and evaluation."

Provided by University of Pennsylvania APA citation: Skid row cancer study has implications for treatment today, researcher says (2013, October 18) retrieved 14 May 2018 from


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