Tanya Stoyanova - Stanford CAP Network - Stanford University

Tanya Stoyanova - Stanford CAP Network - Stanford University

Tanya Stoyanova Assistant Professor of Radiology (Cancer Early Detection-Canary Center) CONTACT INFORMATION • Alternate Contact Toni Benevento - Admi...

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Tanya Stoyanova Assistant Professor of Radiology (Cancer Early Detection-Canary Center)

CONTACT INFORMATION • Alternate Contact Toni Benevento - Administrative Associate Email [email protected] Tel (650) 723-4212

Bio ACADEMIC APPOINTMENTS

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Assistant Professor, Radiology Member, Bio-X Member, Stanford Cancer Institute

HONORS AND AWARDS

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McCormick and Gabilan Faculty Award, Stanford University (2016-2018) K99/R00 Pathway to Independence Award, National Institute of Health/National Cancer Institute (2014-2019) 2014 Stewart Rahr Prostate Cancer Foundation Young Investigator Award, Prostate Cancer Foundation (2014-2017) 2014 Department of Pharmacology Retreat Award, University of California, Los Angeles, CA (2014) Chancellor's Award for Postdoctoral Research, University of California, Los Angeles, CA (2014) Postdoctoral Fellowship. Prostate Cancer Research Program, Department of Defense (2012-2014) Postdoctoral Fellowship, California Institute for Regenerative Medicine (2010-2012) SIGMA Xi Student Research Forum Award for Graduate and Professional Students 2008, University of Illinois, Chicago, IL (2008) SIGMA Xi Student Research Forum Award for Graduate and Professional Students 2007, University of Illinois, Chicago, IL (2007) Sally Frost Mason Outstanding Woman Student in Biological Sciences 2003, University of Kansas, Lawrence, KS (2003) Sally K. Frost Mason and Kenneth A. Mason Outstanding Senior 2003. Division of Biological Sciences, University of Kansas, Lawrence, KS (2003) Ruben Zadigan Environmental Studies Scholarship, University of Kansas, Lawrence, KS (2001-2003)

PROFESSIONAL EDUCATION

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Postdoctoral, University of California, Los Angeles, CA, USA , Stem cell and Cancer Biology (2015) PhD, University of Illinois, Chicago, IL, USA , Biochemistry and Molecular Genetics (2009) BS, University of Kansas, Lawrence, KS, USA , Genetics (2003) BS, Technical University of Varna, Varna, Bulgaria , Ecology and Protection of the Environment (2002)

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Tanya Stoyanova http://cap.stanford.edu/profiles/Tanya_Stoyanova/ LINKS



Stoyanova Lab: http://med.stanford.edu/stoyanovalab.html

Research & Scholarship CURRENT RESEARCH AND SCHOLARLY INTERESTS Our research focuses on understanding fundamental molecular mechanisms underlying cancer development. Currently, we study signaling cascades initiated by cell surface receptors which are involved in: 1) the early event of prostate cancer initiation and 2) regulation of the transition from indolent to metastatic disease. The long term goal of our laboratory is to improve the stratification of indolent from aggressive prostate cancer and aid the development of better therapeutic strategies for the advanced disease.

Additionally, we are interested in understanding molecular mechanism that govern the self-renewal activity of adult stem cells and cancer stem cells. We use molecular biology techniques, cell culture based adult stem cell assays, in vivo tissue regeneration models of cancer.

Teaching STANFORD ADVISEES Postdoctoral Faculty Sponsor Ali Ghoochani, En-Chi Hsu, Meghan Rice

Publications PUBLICATIONS



The Exosome Total Isolation Chip. ACS nano Liu, F., Vermesh, O., Mani, V., Ge, T. J., Madsen, S. J., Sabour, A., Hsu, E. C., Gowrishankar, G., Kanada, M., Jokerst, J. V., Sierra, R. G., Chang, E., Lau, et al 2017



Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome CELL REPORTS Liu, X., Grogan, T. R., Hieronymus, H., Hashimoto, T., Mottahedeh, J., Cheng, D., Zhang, L., Huang, K., Stoyanova, T., Park, J. W., Shkhyan, R. O., Nowroozizadeh, B., Rettig, et al 2016; 17 (10): 2596-2606



v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1 CANCER RESEARCH Ju, X., Jiao, X., Ertel, A., Casimiro, M. C., Di Sante, G., Deng, S., Li, Z., Di Rocco, A., Zhan, T., Hawkins, A., Stoyanova, T., Ando, S., Fatatis, et al 2016; 76 (22): 6723-6734



Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Stoyanova, T., Riedinger, M., Lin, S., Faltermeier, C. M., Smith, B. A., Zhang, K. X., Going, C. C., Goldstein, A. S., Lee, J. K., Drake, J. M., Rice, M. A., Hsu, E., Nowroozizadeh, et al 2016; 113 (42): E6457-E6466



Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. Cell Drake, J. M., Paull, E. O., Graham, N. A., Lee, J. K., Smith, B. A., Titz, B., Stoyanova, T., Faltermeier, C. M., Uzunangelov, V., Carlin, D. E., Fleming, D. T., Wong, C. K., Newton, et al 2016; 166 (4): 1041-1054



N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer cell Lee, J. K., Phillips, J. W., Smith, B. A., Park, J. W., Stoyanova, T., McCaffrey, E. F., Baertsch, R., Sokolov, A., Meyerowitz, J. G., Mathis, C., Cheng, D., Stuart, J. M., Shokat, et al 2016; 29 (4): 536-547

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Tanya Stoyanova http://cap.stanford.edu/profiles/Tanya_Stoyanova/



Multidisciplinary intervention of early, lethal metastatic prostate cancer: Report from the 2015 Coffey-Holden Prostate Cancer Academy Meeting PROSTATE Miyahira, A., Lang, J., Den, R., Garraway, I., Lotan, T., Ross, A., Stoyanova, T., Cho, S., Simons, J., Pienta, K., Soule, H. 2015



Distinct phases of human prostate cancer initiation and progression can be driven by different cell-types CANCER CELL MICROENVIRON Stoyanova, T., Goldstein, A. 2014



Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Drake, J. M., Graham, N. A., Lee, J. K., Stoyanova, T., Faltermeier, C. M., Sud, S., Titz, B., Huang, J., Pienta, K. J., Graeber, T. G., Witte, O. N. 2013; 110 (49): E4762-E4769



Identification, characterization and targeting of Docetaxel-resistant prostate cancer cells ASIAN JOURNAL OF ANDROLOGY Stoyanova, T. I., Goldstein, A. S. 2013; 15 (1): 83-84



Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Stoyanova, T., Cooper , A., Drake, J., Liu, X., Armstrong, A., Pienta, K., Zhang , H., Kohn, D., Huang, J., Witte, O., Goldstein, A. 2013



Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via beta-catenin signaling GENES & DEVELOPMENT Stoyanova, T., Goldstein, A. S., Cai, H., Drake, J. M., Huang, J., Witte, O. N. 2012; 26 (20): 2271-2285



Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer CANCER RESEARCH Cai, H., Memarzadeh, S., Stoyanova, T., Beharry, Z., Kraft, A. S., Witte, O. N. 2012; 72 (18): 4672-4681



Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Drake, J. M., Graham, N. A., Stoyanova, T., Sedghi, A., Goldstein, A. S., Cai, H., Smith, D. A., Zhang, H., Komisopoulou, E., Huang, J., Graeber, T. G., Witte, O. N. 2012; 109 (5): 1643-1648



p21 Cooperates with DDB2 Protein in Suppression of Ultraviolet Ray-induced Skin Malignancies JOURNAL OF BIOLOGICAL CHEMISTRY Stoyanova, T., Roy, N., Bhattacharjee, S., Kopanja, D., Valli, T., Bagchi, S., Raychaudhuri, P. 2012; 287 (5): 3019-3028



Cul4A is essential for spermatogenesis and male fertility DEVELOPMENTAL BIOLOGY Kopanja, D., Roy, N., Stoyanova, T., Hess, R. A., Bagchi, S., Raychaudhuri, P. 2011; 352 (2): 278-287



Primitive origins of prostate cancer: In vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells MOLECULAR ONCOLOGY Goldstein, A. S., Stoyanova, T., Witte, O. N. 2010; 4 (5): 385-396



DDB2 (Damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response CELL CYCLE Stoyanova, T., Roy, N., Kopanja, D., Raychaudhuri, P., Bagchi, S. 2009; 8 (24): 4067-4071



Proliferation defects and genome instability in cells lacking Cul4A ONCOGENE Kopanja, D., Stoyanova, T., Okur, M. N., Huang, E., Bagchi, S., Raychaudhuri, P. 2009; 28 (26): 2456-2465



DDB2 decides cell fate following DNA damage PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Stoyanova, T., Roy, N., Kopanja, D., Bagchi, S., Raychaudhuri, P.

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Tanya Stoyanova http://cap.stanford.edu/profiles/Tanya_Stoyanova/ 2009; 106 (26): 10690-10695



The xeroderma pigmentosum group E gene product DDB2 activates nucleotide excision repair by regulating the level of p21(Waf1/Cip1) MOLECULAR AND CELLULAR BIOLOGY Stoyanova, T., Yoon, T., Kopanja, D., Mokyr, M. B., Raychaudhuri, P. 2008; 28 (1): 177-187

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